ArticleScientific reports2017
Elucidation of Plasma-induced Chemical Modifications on Glutathione and Glutathione Disulphide.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 46 citations in OpenAlex.
- The Cold Atmospheric Plasma Inhibits Cancer Proliferation Through Reducing Glutathione Synthesis.Molecules (Basel, Switzerland) · 2025Article
- Chemical modification of selenium-containing amino acids caused by non-thermal dielectric-barrier discharge atmospheric-pressure plasma.RSC advances · 2024Article
- Does non-thermal plasma modify biopolymers in solution? A chemical and mechanistic study for alginate.Biomaterials science · 2023Article
- Efficacy of plasma activated saline in a co-culture infection control model.Scientific reports · 2022Article
- Article
- Catalytic oxidation of small organic molecules by cold plasma in solution in the presence of molecular iron complexesScientific reports · 2020Article
- Plasma-Driven in Situ Production of Hydrogen Peroxide for Biocatalysis.ChemSusChem · 2020Article
- On a heavy path - determining cold plasma-derived short-lived species chemistry using isotopic labelling.RSC advances · 2020Article
- Study on Chemical Modifications of Glutathione by Cold Atmospheric Pressure Plasma (Cap) Operated in Air in the Presence of Fe(II) and Fe(III) Complexes.Scientific reports · 2019Article
- Multimodal Nonlinear Microscopy for Therapy Monitoring of Cold Atmospheric Plasma Treatment.Micromachines · 2019Article
- The molecular chaperone Hsp33 is activated by atmospheric-pressure plasma protecting proteins from aggregation.Journal of the Royal Society, Interface · 2019Article
- Nitrosylation vs. oxidation - How to modulate cold physical plasmas for biological applications.PloS one · 2019Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cold atmospheric pressure plasmas are gaining increased interest in the medical sector and clinical trials to treat skin diseases are underway. Plasmas are capable of producing several reactive oxygen and nitrogen species (RONS). However, there are open questions how plasma-generated RONS interact on a molecular level in a biological environment, e.g. cells or cell components. The redox pair glutathione (GSH) and glutathione disulphide (GSSG) forms the most important redox buffer in organisms responsible for detoxification of intracellular reactive species. We apply Raman spectroscopy, mass spectrometry, and molecular dynamics simulations to identify the time-dependent chemical modifications on GSH and GSSG that are caused by dielectric barrier discharge under ambient conditions. We find GSSG, S-oxidised glutathione species, and S-nitrosoglutathione as oxidation products with the latter two being the final products, while glutathione sulphenic acid, glutathione sulphinic acid, and GSSG are rather reaction intermediates. Experiments using stabilized pH conditions revealed the same main oxidation products as were found in unbuffered solution, indicating that the dominant oxidative or nitrosative reactions are not influenced by acidic pH. For more complex systems these results indicate that too long treatment times can cause difficult-to-handle modifications to the cellular redox buffer which can impair proper cellular function.
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