Evidence map›Paper›PMID 29062048›Full record

ArticleScientific reports2017

Nacre-mimic Reinforced Ag@reduced Graphene Oxide-Sodium Alginate Composite Film for Wound Healing.

Xu Yan, Fei Li, Kang-Di Hu, Jingzhe Xue, Xiao-Feng Pan, Tao He, Liang Dong, Xiang-Ying Wang, Ya-Dong Wu, Yong-Hong Song and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Graphene-Based Scaffolds for Regenerative Medicine.Nanomaterials (Basel, Switzerland) · 2021
    Review
  3. Graphene-Based Antimicrobial Biomedical Surfaces.Chemphyschem : a European journal of chemical physics and physical chemistry · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xu YanDepartment of Pharmacy, Anhui Province Hospital, Hefei, Anhui, 230001, P. R. China.
Fei LiSchool of Chemistry and Chemical Engineering, School of Food Science and Engineering, Hefei University of Technology, Hefei, 230009, P. R. China.
Kang-Di HuSchool of Chemistry and Chemical Engineering, School of Food Science and Engineering, Hefei University of Technology, Hefei, 230009, P. R. China.
Jingzhe XueCollege of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong, 518060, P. R. China. jzxue@ustc.edu.cn.
Xiao-Feng PanSchool of Chemistry and Chemical Engineering, School of Food Science and Engineering, Hefei University of Technology, Hefei, 230009, P. R. China.
Tao HeSchool of Chemistry and Chemical Engineering, School of Food Science and Engineering, Hefei University of Technology, Hefei, 230009, P. R. China.
Liang DongDepartment of Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026, P. R. China.
Xiang-Ying WangSchool of Chemistry and Chemical Engineering, School of Food Science and Engineering, Hefei University of Technology, Hefei, 230009, P. R. China.
Ya-Dong WuSchool of Chemistry and Chemical Engineering, School of Food Science and Engineering, Hefei University of Technology, Hefei, 230009, P. R. China.
Yong-Hong SongSchool of Chemistry and Chemical Engineering, School of Food Science and Engineering, Hefei University of Technology, Hefei, 230009, P. R. China.
Wei-Ping XuDepartment of Pharmacy, Anhui Province Hospital, Hefei, Anhui, 230001, P. R. China. xwp5606@163.com.
Yang LuSchool of Chemistry and Chemical Engineering, School of Food Science and Engineering, Hefei University of Technology, Hefei, 230009, P. R. China. yanglu@hfut.edu.cn.ORCID 0000-0002-8412-809X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the emerging of drug-resistant bacterial and fungal pathogens, there raise the interest of utilizing versatile antimicrobial biomaterials to treat the acute wound. Herein, we report the spraying mediated assembly of a bio-inspired Ag@reduced graphene-sodium alginate (AGSA) composite film for effective wound healing. The obtained film displayed lamellar microstructures similar to the typical "brick-and-mortar" structure in nacre. In this nacre-mimic structure, there are abundant interfacial interactions between nanosheets and polymeric matrix, leading to remarkable reinforcement. As a result, the tensile strength, toughness and Young's modulus have been improved 2.8, 2.3 and 2.7 times compared with pure sodium alginate film, respectively. In the wound healing study, the AGSA film showed effective antimicrobial activities towards Pseudomonas aeruginosa, Escherichia coli and Candida albicans, demonstrating the ability of protecting wound from pathogenic microbial infections. Furthermore, in vivo experiments on rats suggested the effect of AGSA film in promoting the recovery of wound sites. According to MTT assays, heamolysis evaluation and in vivo toxicity assessment, the composite film could be applied as a bio-compatible material in vitro and in vivo. Results from this work indicated such AGSA film has promising performance for wound healing and suggested great potential for nacre-mimic biomaterials in tissue engineering applications.

Indexed as

Cell ProliferationWound HealingAlginatesAnimalsBiomimeticsElastic ModulusGraphiteHumansHuman Umbilical Vein Endothelial CellsMaleMaterials TestingNacreOxidesRatsRats, Sprague-DawleySilverAlginatesgraphene oxideGraphiteNacreOxidesSilverSodium Compoundssodium oxide

Identifiers

PMID29062048
PMCPMC5653744

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.