ArticleScientific reports2017
How aging impacts skin biomechanics: a multiscale study in mice.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 70 citations in OpenAlex.
- Article
- Promoting collagen synthesis: a viable strategy to combat skin ageing.Journal of enzyme inhibition and medicinal chemistry · 2025Review
- Strongyloides species exhibit distinct behaviors on the skin of different mammals.BMC infectious diseases · 2025Article
- Efficacy and safety of umbilical cord-derived mesenchymal stem cell-conditioned media for preventing and treating skin aging.World journal of stem cells · 2025Article
- Quantification of age-related changes in the structure and mechanical function of skin with multiscale imaging.GeroScience · 2024Article
- Mechanical Models of Collagen Networks for Understanding Changes in the Failure Properties of Aging Skin.Journal of biomechanical engineering · 2024Article
- The role of interface geometry and appendages on the mesoscale mechanics of the skin.Biomechanics and modeling in mechanobiology · 2024Article
- Antioxidants in Photoaging: From Molecular Insights to Clinical Applications.International journal of molecular sciences · 2024Review
- Elastic fiber alterations and calcifications in calcific uremic arteriolopathy.Scientific reports · 2023Article
- Article
- Multiscale Computational Model Predicts Mouse Skin Kinematics Under Tensile Loading.Journal of biomechanical engineering · 2022Article
- A mechanistic view on the aging human skin through ex vivo layer-by-layer analysis of mechanics and microstructure of facial and mammary dermis.Scientific reports · 2022Article
- The cellular mechanobiology of aging: from biology to mechanics.Annals of the New York Academy of Sciences · 2021Review
- Changes in the three-dimensional microscale topography of human skin with aging impact its mechanical and tribological behavior.PloS one · 2021Article
- Three-Dimensional Quantification of Collagen Microstructure During Tensile Mechanical Loading of Skin.Frontiers in bioengineering and biotechnology · 2021Article
- Tissue Mechanics in Haired Murine Skin: Potential Implications for Skin Aging.Frontiers in cell and developmental biology · 2021Article
- Tissue-scale tensional homeostasis in skin regulates structure and physiological function.Communications biology · 2020Article
- The bioengineering theory of the key modes of action of a cyanoacrylate liquid skin protectant.International wound journal · 2020Article
- In vivo imaging of the depth-resolved optic axis of birefringence in human skin.Optics letters · 2020Article
- Skin Structure-Function Relationships and the Wound Healing Response to Intrinsic Aging.Advances in wound care · 2020Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin aging is a complex process that strongly affects the mechanical behavior of skin. This study aims at deciphering the relationship between age-related changes in dermis mechanical behavior and the underlying changes in dermis microstructure. To that end, we use multiphoton microscopy to monitor the reorganization of dermal collagen during mechanical traction assays in ex vivo skin from young and old mice. The simultaneous variations of a full set of mechanical and microstructural parameters are analyzed in the framework of a multiscale mechanical interpretation. They show consistent results for wild-type mice as well as for genetically-modified mice with modified collagen V synthesis. We mainly observe an increase of the tangent modulus and a lengthening of the heel region in old murine skin from all strains, which is attributed to two different origins that may act together: (i) increased cross-linking of collagen fibers and (ii) loss of water due to proteoglycans deterioration, which impedes inner sliding within these fibers. In contrast, the microstructure reorganization upon stretching shows no age-related difference, which can be attributed to opposite effects of the decrease of collagen content and of the increase of collagen cross-linking in old mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.