ArticleNature communications2017
Hierarchical control of enzymatic actuators using DNA-based switchable memories.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Active Oscillations of Elastic Membranes Arising from the Coupling with a Catalytic Reaction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Functions and applications of enzymes in nucleic acid nanotechnology.Journal of nanobiotechnology · 2025Review
- DNA computing function switching by programming base stacking interactions with minimal molecular architecture changes.Nature communications · 2025Article
- Bistable Functions and Signaling Motifs in Systems Chemistry: Taking the Next Step Toward Synthetic Cells.Accounts of chemical research · 2025Review
- DNA as a universal chemical substrate for computing and data storage.Nature reviews. Chemistry · 2024Review
- Directing Uphill Strand Displacement with an Engineered Superhelicase.ACS synthetic biology · 2023Article
- Standardized excitable elements for scalable engineering of far-from-equilibrium chemical networks.Nature chemistry · 2022Article
- Synthesis of Protein-Oligonucleotide Conjugates.Biomolecules · 2022Review
- A Bayesian Approach to Extracting Kinetic Information from Artificial Enzymatic Networks.Analytical chemistry · 2022Article
- Development of Synthetic DNA Circuit and Networks for Molecular Information Processing.Nanomaterials (Basel, Switzerland) · 2021Review
- Feedback and Communication in Active Hydrogel Spheres with pH Fronts: Facile Approaches to Grow Soft Hydrogel Structures.Angewandte Chemie (International ed. in English) · 2021Article
- A small-molecule chemical interface for molecular programs.Nucleic acids research · 2021Article
- Signaling in Systems Chemistry: Programing Gold Nanoparticles Formation and Assembly Using a Dynamic Bistable Network.Angewandte Chemie (International ed. in English) · 2021Article
- Optimizing enzymatic catalysts for rapid turnover of substrates with low enzyme sequestration.Biological cybernetics · 2020Article
- Review
- Building in vitro transcriptional regulatory networks by successively integrating multiple functional circuit modules.Nature chemistry · 2019Article
- A modular degron library for synthetic circuits in mammalian cells.Nature communications · 2019Article
- T7 RNA polymerase non-specifically transcribes and induces disassembly of DNA nanostructures.Nucleic acids research · 2018Article
- Computing with biological switches and clocks.Natural computing · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Inspired by signaling networks in living cells, DNA-based programming aims for the engineering of biochemical networks capable of advanced regulatory and computational functions under controlled cell-free conditions. While regulatory circuits in cells control downstream processes through hierarchical layers of signal processing, coupling of enzymatically driven DNA-based networks to downstream processes has rarely been reported. Here, we expand the scope of molecular programming by engineering hierarchical control of enzymatic actuators using feedback-controlled DNA-circuits capable of advanced regulatory dynamics. We developed a translator module that converts signaling molecules from the upstream network to unique DNA strands driving downstream actuators with minimal retroactivity and support these findings with a detailed computational analysis. We show our modular approach by coupling of a previously engineered switchable memories circuit to downstream actuators based on β-lactamase and luciferase. To the best of our knowledge, our work demonstrates one of the most advanced DNA-based circuits regarding complexity and versatility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.