ArticleNature communications2017
αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis.
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05637216 (A Pilot Study of Losartan to Reduce Radiation Induced Fibrosis in Breast Cancer Patients), which is not on this map. Cited by 64 papers.
0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT05637216 phase2active not recruitingnot on this mapstarted 2023, after this paper: background citation
A Pilot Study of Losartan to Reduce Radiation Induced Fibrosis in Breast Cancer Patients
Who cites it
64 citing papers in PubMed, 101 citations in OpenAlex.
- Epigenetic insights of Olympic champions: nuclear and mitochondrial DNA methylation and regulators of aging.GeroScience · 2026Article
- CDCP1 Deletion Protects Against Pressure Overload-Induced Cardiac Dysfunction and Fibrosis in Mice.Research square · 2026Article
- Inflammation drives TGFβ1 activation via the αvβ6 integrin-mechanotransduction pathway in human skin.iScience · 2026Article
- Integrin αScientific reports · 2026Article
- Mouse Models of Muscle Fibrosis: Mechanisms, Methods, and Applications.Biomedicines · 2026Review
- PDGFRβ in Stem Cell Microenvironments: Cross-Tissue Evidence and Hypotheses for the Limbal Stem Cell Niche.Stem cells international · 2026Review
- Surface marker-defined functional subpopulations of mesenchymal stromal cells: mechanisms, applications, and clinical translation.Frontiers in bioengineering and biotechnology · 2026Review
- Transcriptome Analysis IdentifiedJournal of the American Heart Association · 2025Article
- miR-3606-3p alleviates skin fibrosis by integratively suppressing the integrin/FAK, p-AKT/p-ERK, and TGF-β signaling cascades.Journal of advanced research · 2025Article
- SMAD7: riding on fibrosis-limiting routes and beyond.EMBO molecular medicine · 2025Review
- RNA aptamer-mediated RNA nanotechnology for potential treatment of cardiopulmonary diseases.Pharmacological research · 2025Review
- An optimized plasmalogen modulating dietary supplement provides greater protection in a male than female mouse model of dilated cardiomyopathy.Journal of molecular and cellular cardiology plus · 2025Article
- Using Integrin αInternational journal of radiation oncology, biology, physics · 2025Article
- Lineage tracing reveals a novel PDGFRβScientific reports · 2024Article
- Roles of Integrin in Cardiovascular Diseases: From Basic Research to Clinical Implications.International journal of molecular sciences · 2024Review
- Benzoylaconine Protects Skeletal Muscle Against Ischemia-Reperfusion Injury Through Activation of IF1-Dependent AMPK/Nrf2 Axis.Drug design, development and therapy · 2024Article
- New from old: recycling differentiated cells into regenerative cells using traditional Chinese medicine? A tribute to Professor Rongxiang Xu.Frontiers in bioengineering and biotechnology · 2024Article
- Role of perivascular cells in kidney homeostasis, inflammation, repair and fibrosis.Nature reviews. Nephrology · 2023Review
- Kinin receptors regulate skeletal muscle regeneration: differential effects for B1 and B2 receptors.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Article
- Aldehyde Dehydrogenase, a Marker of Normal and Malignant Stem Cells, Typifies Mesenchymal Progenitors in Perivascular Niches.Stem cells translational medicine · 2023Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 9 institutions in 2 countries.
I R MurrayDepartment of Trauma and Orthopaedics, University of Edinburgh, Chancellors Building, Little France Campus, Edinburgh, EH16 4TJ, UK.
Z N GonzalezBHF Centre for Vascular Regeneration & MRC Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK.
J BailyBHF Centre for Vascular Regeneration & MRC Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK.
R DobieMRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
R J WallaceDepartment of Trauma and Orthopaedics, University of Edinburgh, Chancellors Building, Little France Campus, Edinburgh, EH16 4TJ, UK.
A C MackinnonMRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
J R SmithMRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
S N GreenhalghMRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
A I ThompsonMRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
K P ConroyMRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
D W GriggsCenter for World Health and Medicine, Saint Louis University, Edward A. Doisy Research Center, St. Louis, MO 63104, USA.
P G RuminskiCenter for World Health and Medicine, Saint Louis University, Edward A. Doisy Research Center, St. Louis, MO 63104, USA.
G A GrayBHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
M SinghCenter for World Health and Medicine, Saint Louis University, Edward A. Doisy Research Center, St. Louis, MO 63104, USA.
M A CampbellCenter for World Health and Medicine, Saint Louis University, Edward A. Doisy Research Center, St. Louis, MO 63104, USA.
T J KendallMRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.ORCID http://orcid.org/0000-0002-4174-2786
J DaiDepartment of Pediatric Surgery, University of Texas McGovern Medical School, TX, 77030, USA.
Y LiDepartment of Pediatric Surgery, University of Texas McGovern Medical School, TX, 77030, USA.
J P IredaleUniversity of Bristol, Senate House, Tyndall Avenue, Bristol, BS8 1TH, UK.
H SimpsonDepartment of Trauma and Orthopaedics, University of Edinburgh, Chancellors Building, Little France Campus, Edinburgh, EH16 4TJ, UK.
J HuardSteadman Philippon Research Institute, Vail, CO 81657, USA.
B PéaultBHF Centre for Vascular Regeneration & MRC Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK. bpeault@mednet.ucla.edu.
N C HendersonMRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK. Neil.Henderson@ed.ac.uk.
Centre for Inflammation Research · GBSaint Louis University · USMRC Centre for Regenerative Medicine · GBBrown Foundation · USUniversity of Edinburgh · GBTexas Medical Center · USThe Queen's Medical Research Institute · GBUniversity of Bristol · GBUniversity of California, Los Angeles · US
Funding
British Heart Foundation RM/13/2/30158British Heart Foundation SRG/15/80Medical Research Council G0401643Medical Research Council G0600033Medical Research Council G0800682Medical Research Council G0900550Medical Research Council G0901697Medical Research Council G1000816Medical Research Council G1000868Medical Research Council MC_PC_15041Medical Research Council MR/J003611/1Medical Research Council MR/K017047/1Wellcome Trust 097483Wellcome Trust 103749
Abstract
Mesenchymal cells expressing platelet-derived growth factor receptor beta (PDGFRβ) are known to be important in fibrosis of organs such as the liver and kidney. Here we show that PDGFRβ
Indexed as
AnimalsApoptosisCell MovementCells, CulturedCollagenFibrosisGenotypeHumansIntegrin alphaVMaleMesenchymal Stem CellsMiceMice, Inbred C57BLMice, TransgenicMuscle, SkeletalMyocardiumCollagenIntegrin alphaVReceptor, Platelet-Derived Growth Factor betaRecombinant Proteins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT05637216ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.