Evidence map›Paper›PMID 29061960›Full record

ArticleNature communications2017

Single-cell mass cytometry and transcriptome profiling reveal the impact of graphene on human immune cells.

Marco Orecchioni, Davide Bedognetti, Leon Newman, Claudia Fuoco, Filomena Spada, Wouter Hendrickx, Francesco M Marincola, Francesco Sgarrella, Artur Filipe Rodrigues, Cécilia Ménard-Moyon and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 134 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 6 countries.

Marco OrecchioniDepartment of Chemistry and Pharmacy University of Sassari, Sassari, 07100, Italy.
Davide BedognettiImmunology and Therapy Section, Division of Translational Medicine, Sidra Medical and Research Center, Doha, Qatar.ORCID http://orcid.org/0000-0002-5857-773X
Leon NewmanNanomedicine Laboratory, Faculty of Biology, Medicine & Health, and National Graphene Institute University of Manchester, Manchester, M13 9PL, UK.
Claudia FuocoDepartment of Biology, University of Rome Tor Vergata, Rome, 00133, Italy.
Filomena SpadaDepartment of Biology, University of Rome Tor Vergata, Rome, 00133, Italy.
Wouter HendrickxImmunology and Therapy Section, Division of Translational Medicine, Sidra Medical and Research Center, Doha, Qatar.ORCID http://orcid.org/0000-0002-7649-5092
Francesco M MarincolaOffice of the Chief Research Officer, Sidra Medical and Research Center, Doha, Qatar.ORCID http://orcid.org/0000-0001-6423-391X
Francesco SgarrellaDepartment of Chemistry and Pharmacy University of Sassari, Sassari, 07100, Italy.
Artur Filipe RodriguesNanomedicine Laboratory, Faculty of Biology, Medicine & Health, and National Graphene Institute University of Manchester, Manchester, M13 9PL, UK.ORCID http://orcid.org/0000-0002-4078-3455
Cécilia Ménard-MoyonCNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunopathologie et Chimie Thérapeutique, Strasbourg, 67 084, France.
Gianni CesareniDepartment of Biology, University of Rome Tor Vergata, Rome, 00133, Italy.ORCID http://orcid.org/0000-0002-9528-6018
Kostas KostarelosNanomedicine Laboratory, Faculty of Biology, Medicine & Health, and National Graphene Institute University of Manchester, Manchester, M13 9PL, UK. kostas.kostarelos@manchester.ac.uk.ORCID http://orcid.org/0000-0002-2224-6672
Alberto BiancoCNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunopathologie et Chimie Thérapeutique, Strasbourg, 67 084, France. a.bianco@ibmc-cnrs.unistra.fr.ORCID http://orcid.org/0000-0002-1090-296X
Lucia G DeloguDepartment of Chemistry and Pharmacy University of Sassari, Sassari, 07100, Italy. lgdelogu@uniss.it.ORCID http://orcid.org/0000-0002-2329-7260
University of Manchester · GBUniversity of Rome Tor Vergata · ITUniversity of Sassari · ITCentre National de la Recherche Scientifique · FRSidra Medical and Research Center · QAAbbVie (United States) · US

Funding

European Research Council 322749Wellcome Trust
6 · The paper itself

Abstract

Understanding the biomolecular interactions between graphene and human immune cells is a prerequisite for its utilization as a diagnostic or therapeutic tool. To characterize the complex interactions between graphene and immune cells, we propose an integrative analytical pipeline encompassing the evaluation of molecular and cellular parameters. Herein, we use single-cell mass cytometry to dissect the effects of graphene oxide (GO) and GO functionalized with amino groups (GONH

Indexed as

AdultFemaleFlow CytometryGene Expression ProfilingGraphiteHumansMaleMiddle AgedOxidesSingle-Cell AnalysisTh1 CellsT-LymphocytesGraphiteOxides

Identifiers

PMID29061960
PMCPMC5653675
OpenAlexW2766365110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.