Evidence map›Paper›PMID 29061848›Full record

ArticleThe Journal of biological chemistry2017

A herpesvirus entry mediator mutein with selective agonist action for the inhibitory receptor B and T lymphocyte attenuator.

John R Šedý, M Olivia Balmert, Brian C Ware, Wendell Smith, Ivana Nemčovičova, Paula S Norris, Brian R Miller, Dikran Aivazian, Carl F Ware

Open access · hybridAbstract readComparative Study
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. MutantFrontiers in immunology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Structural Basis of CD160:HVEM Recognition.Structure (London, England : 1993) · 2019
    Article
  16. Article
  17. Cytomegalovirus: Shape-Shifting the Immune System.Journal of immunology (Baltimore, Md. : 1950) · 2018
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

John R ŠedýFrom the Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, jsedy@sbpdiscovery.org.
M Olivia BalmertFrom the Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037.
Brian C WareFrom the Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037.
Wendell SmithFrom the Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037.
Ivana Nemčovičovathe Biomedical Research Center, Slovak Academy of Sciences, SK 84505, Bratislava, Slovakia, and.
Paula S NorrisFrom the Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037.
Brian R Millerthe Centers for Therapeutic Innovation, Pfizer Inc., La Jolla, California 92037.
Dikran Aivazianthe Centers for Therapeutic Innovation, Pfizer Inc., La Jolla, California 92037.
Carl F WareFrom the Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, cware@sbpdiscovery.org.
Sanford Burnham Prebys Medical Discovery Institute · USBiomedical Research Center of the Slovak Academy of Sciences · SKCenters for New Horizons · USDiscovery Institute · USPfizer (United States) · US

Funding

Virology CoreP01CA177322 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUN, REN · 2014 to 2018
$8.7M
Anti-herpesvirus Signaling by LTalphabeta/LIGHT CytokinesR01AI048073 · NIAID · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI WARE, CARL F · 2001 to 2016
$7.0M
HVEM-BTLA system in InflammationR01AI067890 · NIAID · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI WARE, CARL F · 2007 to 2016
$4.3M
HVEM-BTLA Pathway in LymphomaR01CA164679 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI WARE, CARL F · 2012 to 2016
$2.0M
American Heart Association-American Stroke Association 14BGIA20380277NCI NIH HHS P01 CA177322NCI NIH HHS R01 CA164679NIAID NIH HHS R01 AI048073NIAID NIH HHS R01 AI067890
6 · The paper itself

Abstract

The human cytomegalovirus opening reading frame UL144 is an ortholog of the TNF receptor superfamily member, herpesvirus entry mediator (HVEM;

Indexed as

Models, MolecularAmino Acid SubstitutionAntigens, CDAnti-Inflammatory Agents, Non-SteroidalBinding SitesB-LymphocytesCell Line, TumorDrug DesignGPI-Linked ProteinsHEK293 CellsHumansKiller Cells, NaturalKineticsLigandsMembrane GlycoproteinsMutationAntigens, CDAnti-Inflammatory Agents, Non-SteroidalBTLA protein, humanCD160 protein, humanGPI-Linked ProteinsLigandsMembrane GlycoproteinsReceptors, ImmunologicReceptors, Tumor Necrosis Factor, Member 14Recombinant Fusion ProteinsTNFRSF14 protein, humanUL144 ORF protein, Human herpesvirus 5Viral Proteinscytokineherpesvirusimmunologylymphocytereceptor structure-functionsignal transductionstructural biologystructural modelviral immunology

Identifiers

PMID29061848
PMCPMC5743079
OpenAlexW2766378499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.