Evidence map›Paper›PMID 29061746›Full record

Trial reportAntimicrobial agents and chemotherapy2018

Efficacy and Tolerability Outcomes of a Phase II, Randomized, Open-Label, Multicenter Study of a New Water-Dispersible Pediatric Formulation of Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in African Infants.

Nicola Gargano, Lola Madrid, Giovanni Valentini, Umberto D'Alessandro, Tinto Halidou, Sodiomon Sirima, Antoinette Tshefu, Ali Mtoro, Samwel Gesase, Eurartesim Dispersible Study Group and 1 more

Open access · hybridAbstract readClinical Trial, Phase IIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 7 countries.

Nicola GarganoSigma-Tau Industrie Farmaceutiche Riunite S.p.A., Rome, Italy.
Lola MadridCentro de Investigação em Saúde de Manhiça, Maputo, Mozambique.
Giovanni ValentiniSigma-Tau Industrie Farmaceutiche Riunite S.p.A., Rome, Italy.
Umberto D'AlessandroMedical Research Council Unit, The Gambia, The Gambia.
Tinto HalidouCentre Muraz Bobo-Dioulasso, Nanoro, Burkina Faso.
Sodiomon SirimaCentre National de Recherche et de Formation en Paludisme, Ouagadougou, Burkina Faso.
Antoinette TshefuKinshasa School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Ali MtoroIfakara Health Institute, Bagamoyo, Tanzania.
Samwel GesaseNational Institute for Medical Research, Korogwe, Tanzania.
Eurartesim Dispersible Study Group
Quique BassatCentro de Investigação em Saúde de Manhiça, Maputo, Mozambique quique.bassat@isglobal.org.ORCID 0000-0003-0875-7596
Institució Catalana de Recerca i Estudis Avançats · ESSigma Tau (Italy) · ITCentre Muraz · BFCentre National de Recherche et de Formation sur le Paludisme · BFIfakara Health Institute · TZManhiça Health Research Centre · MZMRC Unit the Gambia · GMNational Institute for Medical Research · TZUniversity of Kinshasa · CD

Funding

Medical Research Council MC_UP_A900_1119
6 · The paper itself

Abstract

Artemisinin combination therapies are considered the mainstay of malaria treatment, but pediatric-friendly formulations for the treatment of infants are scarce. We sought to evaluate the efficacy and safety of a new dispersible-tablet formulation of dihydroartemisinin/piperaquine phosphate (DHA/PQP) in comparison to the marketed tablet (Eurartesim) in the treatment of infants with uncomplicated

Indexed as

AfricaAntimalarialsArtemisininsDrug CombinationsFemaleHumansInfantKaplan-Meier EstimateMalaria, FalciparumMalePiperazinesQuinolinesTreatment OutcomeAntimalarialsArtemisininsartenimolDrug CombinationspiperaquinePiperazinesQuinolinesAfricaantimalarial agentsdihydroartemisinin-piperaquineinfantsmalaria

Identifiers

PMID29061746
PMCPMC5740378
OpenAlexW2767127869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.