Evidence map›Paper›PMID 29061745›Full record

ArticleAntimicrobial agents and chemotherapy2018

Mechanism of Action of Miltefosine on Leishmania donovani Involves the Impairment of Acidocalcisome Function and the Activation of the Sphingosine-Dependent Plasma Membrane Ca

Andrea K Pinto-Martinez, Jessica Rodriguez-Durán, Xenon Serrano-Martin, Vanessa Hernandez-Rodriguez, Gustavo Benaim

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
8.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 116 citations in OpenAlex.

  1. Review
  2. New Thieno[3,2-Life (Basel, Switzerland) · 2026
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  19. ComparativeFrontiers in pharmacology · 2025
    Article
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Andrea K Pinto-MartinezInstituto de Estudios Avanzados (IDEA), Caracas, Venezuela.
Jessica Rodriguez-DuránInstituto de Estudios Avanzados (IDEA), Caracas, Venezuela.
Xenon Serrano-MartinInstituto de Estudios Avanzados (IDEA), Caracas, Venezuela.
Vanessa Hernandez-RodriguezInstituto de Estudios Avanzados (IDEA), Caracas, Venezuela.
Gustavo BenaimInstituto de Estudios Avanzados (IDEA), Caracas, Venezuela gbenaim@idea.gob.ve.
Instituto de Estudios Avanzados · VE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntiprotozoal AgentsCalciumCalcium Channel AgonistsCalcium Channel BlockersCalcium Channels, L-TypeCell MembraneHomeostasisLeishmania donovaniMembrane Potential, MitochondrialNifedipineOrganellesPhosphorylcholineSphingosineAntiprotozoal AgentsCalciumCalcium Channel AgonistsCalcium Channel BlockersCalcium Channels, L-TypemiltefosineNifedipinePhosphorylcholineSphingosineCa2+Leishmania donovanimechanism of actionmiltefosinesphingosinevisceral leishmaniasis

Identifiers

PMID29061745
PMCPMC5740361
OpenAlexW2766880331

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.