Evidence map›Paper›PMID 29061741›Full record

ArticleAntimicrobial agents and chemotherapy2018

Akinobu Ito, Takafumi Sato, Merime Ota, Miki Takemura, Toru Nishikawa, Shinsuke Toba, Naoki Kohira, Satoshi Miyagawa, Naoki Ishibashi, Shuhei Matsumoto and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 253 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
253citing papers in PubMed, 3 pooled it
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

253 citing papers in PubMed, 3 syntheses or guidelines pooled it, 359 citations in OpenAlex.

  1. Drug-resistantClinical microbiology reviews · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Iron serum levels and iron homeostasis parameters in patients with nosocomial pneumonia treated with cefiderocol: post hoc analysis of the APEKS-NP study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022
    Trial
  6. ISEmerging microbes & infections · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Identification of iron and zinc responsive TonB-dependent transporters in Pseudomonas aeruginosa.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  11. Article
  12. Review
  13. Cefiderocol nonsusceptibility among carbapenem-resistantAntimicrobial agents and chemotherapy · 2026
    Article
  14. Influence of iron uptake systems on cefiderocol activity inAntimicrobial agents and chemotherapy · 2026
    Article
  15. Mechanisms involved in cefiderocol resistance in FrenchAntimicrobial agents and chemotherapy · 2026
    Article
  16. Article
  17. Case Commentary: When susceptibility is not enough in recurrentAntimicrobial agents and chemotherapy · 2026
    Article
  18. Article
  19. Article
  20. Article

193 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Akinobu ItoShionogi & Co., Ltd., Toyonaka, Osaka, Japan akinobu.ito@shionogi.co.jp.
Takafumi SatoShionogi & Co., Ltd., Toyonaka, Osaka, Japan.
Merime OtaShionogi & Co., Ltd., Toyonaka, Osaka, Japan.
Miki TakemuraShionogi & Co., Ltd., Toyonaka, Osaka, Japan.
Toru NishikawaShionogi & Co., Ltd., Toyonaka, Osaka, Japan.
Shinsuke TobaShionogi & Co., Ltd., Toyonaka, Osaka, Japan.
Naoki KohiraShionogi & Co., Ltd., Toyonaka, Osaka, Japan.
Satoshi MiyagawaShionogi & Co., Ltd., Toyonaka, Osaka, Japan.
Naoki IshibashiShionogi & Co., Ltd., Toyonaka, Osaka, Japan.
Shuhei MatsumotoShionogi & Co., Ltd., Toyonaka, Osaka, Japan.ORCID 0000-0003-0377-8304
Rio NakamuraShionogi & Co., Ltd., Toyonaka, Osaka, Japan.
Masakatsu TsujiShionogi & Co., Ltd., Toyonaka, Osaka, Japan.
Yoshinori YamanoShionogi & Co., Ltd., Toyonaka, Osaka, Japan.
Shionogi (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cefiderocol (CFDC; S-649266), a novel parenteral siderophore cephalosporin conjugated with a catechol moiety, has a characteristic antibacterial spectrum with a potent activity against a broad range of aerobic Gram-negative bacterial species, including carbapenem-resistant strains of

Indexed as

Acinetobacter baumanniiAnti-Bacterial AgentsBacterial Outer Membrane ProteinsBacterial ProteinsCarbapenem-Resistant EnterobacteriaceaeCefiderocolCephalosporinsDrug Resistance, Multiple, BacterialEscherichia coliEscherichia coli ProteinsKlebsiella pneumoniaeMembrane Transport ProteinsMicrobial Sensitivity TestsPenicillin-Binding ProteinsPorinsPseudomonas aeruginosaAnti-Bacterial AgentsBacterial Outer Membrane ProteinsBacterial ProteinsCefiderocolCephalosporinscolicin receptor, E coliEscherichia coli ProteinsMembrane Transport ProteinsMexA protein, Pseudomonas aeruginosaMexB protein, Pseudomonas aeruginosaOmpK35 porin, Klebsiella pneumoniaeOmpK36 protein, Klebsiella pneumoniaeOprM protein, Pseudomonas aeruginosaPenicillin-Binding ProteinsPorinsReceptors, Cell Surfacecefiderocolefflux pumpiron transportermorphologyPBPpenicillin-binding proteinporintime kill

Identifiers

PMID29061741
PMCPMC5740388
OpenAlexW2766395453

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.