Evidence map›Paper›PMID 29061706›Full record

ArticleInfection and immunity2018

NLRP3 Is a Critical Regulator of Inflammation and Innate Immune Cell Response during Mycoplasma pneumoniae Infection.

Jesus A Segovia, Te-Hung Chang, Vicki T Winter, Jacqueline J Coalson, Marianna P Cagle, Lavanya Pandranki, Santanu Bose, Joel B Baseman, Thirumalai R Kannan

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 111 citations in OpenAlex.

  1. Review
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  12. Article
  13. World journal of clinical cases · 2025
    Article
  14. Exploring the pathogenetic mechanisms ofExperimental and therapeutic medicine · 2024
    Review
  15. Observational
  16. Association betweenBiomedical reports · 2024
    Review
  17. Clinical characteristics and risk factors forFrontiers in pediatrics · 2024
    Article
  18. Pyroptosis in microbial infectious diseases.Molecular biology reports · 2023
    Review
  19. Article
  20. Review

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jesus A SegoviaDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Te-Hung ChangDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Vicki T WinterDepartment of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Jacqueline J CoalsonDepartment of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Marianna P CagleDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Lavanya PandrankiDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Santanu BoseDepartment of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.
Joel B BasemanDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Thirumalai R KannanDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA kannan@uthscsa.edu.
The University of Texas Health Science Center at San Antonio · USWashington State University · US

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
The role of CARDS toxin in genesis and exacerbation of allergic inflammationU19AI070412 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BASEMAN, JOEL BARRY · 2006 to 2015
$19.7M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR001120 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2013 to 2017
$16.5M
San Antonio Biomedical Education and ResearchK12GM111726 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LECHLEITER, JAMES D, OYAJOBI, BABATUNDE OLUKAYODE · 2015 to 2024
$7.6M
Molecular and cellular mechanism regulating innate immunity and inflammation during pattern recognition receptor activation and respiratory virus infectionR01AI083387 · NIAID · WASHINGTON STATE UNIVERSITY · PI BOSE, SANTANU · 2010 to 2021
$3.1M
Mycoplasma pneumoniae CARDS toxin mediated ADP-ribosylation of NLRP3 inflammasomeR21AI118051 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BOSE, SANTANU, KANNAN, THIRUMALAI RENGASAMY · 2015 to 2016
$429k
NCATS NIH HHS UL1 TR001120NCI NIH HHS P30 CA054174NIAID NIH HHS R01 AI083387NIAID NIH HHS R21 AI118051NIAID NIH HHS U19 AI070412NIGMS NIH HHS K12 GM111726
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsApoptosis Regulatory ProteinsCARD Signaling Adaptor ProteinsCaspase 1Immunity, InnateInflammasomesInflammationInterleukin-1betaMacrophagesMiceMice, Inbred C57BLMycoplasma pneumoniaeMyeloid Differentiation Factor 88NF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinPneumonia, MycoplasmaApoptosis Regulatory ProteinsCARD Signaling Adaptor ProteinsCaspase 1InflammasomesInterleukin-1betaMyeloid Differentiation Factor 88NF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseADP-ribosylationCARDS toxininflammasomeinterleukin-1βMycoplasma pneumoniaeNLRP3

Identifiers

PMID29061706
PMCPMC5736809
OpenAlexW2765913215

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.