ReviewDiabetes2017
The Gastrointestinal Tract as an Integrator of Mechanical and Hormonal Response to Nutrient Ingestion.
Review in Diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 36 citations in OpenAlex.
- One Year of Exercise After Weight Loss Increases Postprandial GLP-1 Secretion in Contrast to Usual Activity or GLP-1 Receptor Agonist Treatment.Obesity (Silver Spring, Md.) · 2026Trial
- Trial
- The Effect of Continuous Intake ofNutrients · 2021Trial
- Hydrophilic Polymers Enable Gastrointestinal Transit Monitoring by Fluorine-19 Magnetic Resonance Imaging.Advanced healthcare materials · 2026Article
- Paradoxical nutrient hyperabsorption despite diarrhea: Insights from jejunal transcriptomic reanalysis in Linghu's obesity-diarrhea syndrome.World journal of gastrointestinal pathophysiology · 2026Review
- Effects of early life adversity on acute metabolic outcomes during neonatal development.Neurobiology of stress · 2026Article
- Peristalsis of the gastric conduit post-esophagectomy: is it relevant? Detailed conduit analysis using dynamic magnetic resonance imaging.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2026Observational
- The relationship between nutritional status and prognosis in advanced gastrointestinal cancer patients in palliative care: a prospective cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Diabetes-associated Genetic Variation inJournal of the Endocrine Society · 2024Article
- Manipulation of Post-Prandial Hyperglycaemia in Type 2 Diabetes: An Update for Practitioners.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- A New Paradigm Shift in Gastroparesis Management.Gut and liver · 2022Review
- Short-Term Partial Replacement of Corn and Soybean Meal with High-Fiber or High-Protein Feedstuffs during Metabolizable Energy Assay Influenced Intestinal Histomorphology, Cecal Short-Chain Fatty Acids, and Selected Nutrient Transporters in 21-Day-Old Broiler Chickens.Animals : an open access journal from MDPI · 2022Article
- The relationship between insulin and glucagon concentrations in non-diabetic humans.Physiological reports · 2022Article
- Effects of Bitter Substances on GI Function, Energy Intake and Glycaemia-Do Preclinical Findings Translate to Outcomes in Humans?Nutrients · 2021Review
- Bitter Melon Extract Yields Multiple Effects on Intestinal Epithelial Cells and Likely Contributes to Anti-diabetic Functions.International journal of medical sciences · 2021Article
- Exploratory Investigation of Intestinal Structure and Function after Stroke in Mice.Mediators of inflammation · 2021Article
- Expression and function of umami receptors T1R1/T1R3 in gastric smooth muscle.Neurogastroenterology and motility · 2020Article
- Eating Disorders and Gastrointestinal Diseases.Nutrients · 2019Review
- Review
- Optimizing Postprandial Glucose Management in Adults With Insulin-Requiring Diabetes: Report and Recommendations.Journal of the Endocrine Society · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Glucose tolerance after meal ingestion in vivo is the result of multiple processes that occur in parallel. Insulin secretion together with reciprocal inhibition of glucagon secretion contributes to glucose tolerance. However, other factors beyond glucose effectiveness and insulin action require consideration. The absorption of ingested nutrients and their subsequent systemic rate of appearance largely depend on the rate of delivery of nutrients to the proximal small intestine. This is determined by the integrated response of the upper gastrointestinal tract to a meal. While gastric emptying is probably the most significant component, other factors need to be considered. This review will examine all processes that could potentially alter the fraction and rate of appearance of ingested nutrients in the peripheral circulation. Several of these processes may be potential therapeutic targets for the prevention and treatment of diabetes. Indeed, there is increased interest in gastrointestinal contributions to nutritional homeostasis, as demonstrated by the advent of antidiabetes therapies that alter gastrointestinal motility, the effect of bariatric surgery on diabetes remission, and the potential of the intestinal microbiome as a modulator of human metabolism. The overall goal of this review is to examine current knowledge of the gastrointestinal contributions to metabolic control.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.