Evidence map›Paper›PMID 29061643›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Phase Ib Study of Immune Biomarker Modulation with Neoadjuvant Cetuximab and TLR8 Stimulation in Head and Neck Cancer to Overcome Suppressive Myeloid Signals.

Gulidanna Shayan, Benjamin A Kansy, Sandra P Gibson, Raghvendra M Srivastava, James Kyle Bryan, Julie E Bauman, James Ohr, Seungwon Kim, Umamaheswar Duvvuri, David A Clump and 4 more

Open access · bronzeAbstract readClinical Trial, Phase I
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 78 citations in OpenAlex.

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  8. Harnessing myeloid cells in cancer.Molecular cancer · 2025
    Review
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  13. Harnessing innate immune pathways for therapeutic advancement in cancer.Signal transduction and targeted therapy · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Gulidanna ShayanSchool of Medicine, Tsinghua University, Beijing, China.
Benjamin A KansyDepartment of Otolaryngology, Essen University Hospital, Essen, Germany.
Sandra P GibsonUPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.
Raghvendra M SrivastavaDepartment of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania.
James Kyle BryanVentiRx Pharmaceuticals Inc., Seattle, Washington.
Julie E BaumanUPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.
James OhrUPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.
Seungwon KimUPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.
Umamaheswar DuvvuriUPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.
David A ClumpUPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.
Dwight E HeronUPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.
Jonas T JohnsonUPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.
Robert M HershbergVentiRx Pharmaceuticals Inc., Seattle, Washington.
Robert L FerrisUPMC Hillman Cancer Center, Pittsburgh, Pennsylvania. ferrrl@upmc.edu.
UPMC Hillman Cancer Center · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
WILD TYPE P53-BASED ADJUVANT IMMUNOTHERAPY FOR SCCHNP50CA097190 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 2004 to 2026
$49.6M
Mechanisms of PD-1 and Tim-3 crosstalk in tumor-infiltrating lymphocytesR01CA206517 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert L. Ferris, Lawrence P. Kane · 2016 to 2026
$4.6M
Postdoctoral Training in Head and Neck OncologyT32CA060397 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZEVALLOS, JOSE P. · 1994 to 2024
$2.7M
Immune activation by cetuximab in head and neck cancer patientsR01DE019727 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FERRIS, ROBERT L. · 2010 to 2014
$2.0M
Inhibition of lysosomal flux in carcinogen-induced head and neck cancerR01DE028343 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUVVURI, UMAMAHESWAR · 2019 to 2023
$1.9M
Novel targets to treat head and neck cancer in VeteransI01BX003456 · VA · VETERANS HEALTH ADMINISTRATION · PI DUVVURI, UMAMAHESWAR · 2017 to 2021
–
BLRD VA I01 BX003456NCI NIH HHS P30 CA047904NCI NIH HHS P50 CA097190NCI NIH HHS R01 CA206517NCI NIH HHS T32 CA060397NIDCR NIH HHS R01 DE019727NIDCR NIH HHS R01 DE028343
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedAntineoplastic Agents, ImmunologicalBiomarkersCD8-Positive T-LymphocytesCell LineCetuximabCytokinesFemaleHead and Neck NeoplasmsHumansImmunomodulationInflammation MediatorsLymphocyte ActivationLymphocytes, Tumor-InfiltratingMaleAntineoplastic Agents, ImmunologicalBiomarkersCetuximabCytokinesInflammation MediatorsTLR8 protein, humanToll-Like Receptor 8

Identifiers

PMID29061643
PMCPMC5754237
OpenAlexW2766148088

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.