SynthesisBMJ open2017
Leisure time physical activity and dementia risk: a dose-response meta-analysis of prospective studies.
Synthesis in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Domain-specific physical activity levels and risk of dementia: a systematic review and meta-analysis.The Lancet. Public health · 2026Pooled it
- Pooled it
- The role of APOE ε4 in modulating the relationship between non-genetic risk factors and dementia: a system review and meta-analysis.Journal of neurology · 2025Pooled it
- Perimenopausal Physical Activity and Dementia Risk: A Systematic Review.International journal of sports medicine · 2024Pooled it
- Physical Activity and Cognitive Decline Among Older Adults: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Physical activity as a protective factor for dementia and Alzheimer's disease: systematic review, meta-analysis and quality assessment of cohort and case-control studies.British journal of sports medicine · 2022Pooled it
- Association between the ferritin level and risk of gestational diabetes mellitus: A meta-analysis of observational studies.Journal of diabetes investigation · 2020Pooled it
- A Systematic Review of Meta-Analyses that Evaluate Risk Factors for Dementia to Evaluate the Quantity, Quality, and Global Representativeness of Evidence.Journal of Alzheimer's disease : JAD · 2019Pooled it
- Mild cognitive impairment and progression to dementia in people with diabetes, prediabetes and metabolic syndrome: a systematic review and meta-analysis.Social psychiatry and psychiatric epidemiology · 2018 · on this mapPooled it
- User experience with two computerized cognitive intervention programs for people with mild cognitive impairment.BMC geriatrics · 2025Trial
- Effects of exercise versus usual care on older adults with amnestic mild cognitive impairment: EXERT versus ADNI.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- The impact of exercise on blood-based biomarkers of Alzheimer's disease in cognitively unimpaired older adults.GeroScience · 2024Trial
- Inter-individual differences in the responses to aerobic exercise in Alzheimer's disease: Findings from the FIT-AD trial.Journal of sport and health science · 2021Trial
- Effect of a wearable-based individualised multidomain lifestyle intervention on cognitive and physical function in older adults at risk of decline (INSPIOR): a single-centre, open-label, randomised controlled trial.EClinicalMedicine · 2026Article
- Physical Activity and Cognitive Function Among Chinese Adults Aged 45 Years and Older with Self-Reported Hearing Loss: A 9-Year Longitudinal Study.Brain and behavior · 2026Observational
- Review
- Feasibility of identifying factors related to Alzheimer's disease and related dementia in real-world data.JAMIA open · 2026Review
- Prevalence and Predictors of Cognitive Decline Among Diabetes Mellitus Patients Attending Jinja Regional Referral Hospital: A Cross-Sectional Study in Eastern Uganda.Health science reports · 2025Article
- Soccer Heading Exposure-Dependent Microstructural Injury at Depths of Sulci in Adult Amateur Players.Neurology · 2025Article
- The association between medical fitness facility attendance and incident mental disorders.Canadian journal of public health = Revue canadienne de sante publique · 2025Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is considerable evidence of the favourable role of more physical activity (PA) in fighting against dementia. However, the shape of the dose-response relationship is still unclear.
objectiveTo quantitatively investigate the relationship between dementia and PA.
designPubMed, EMBASE, Ovid and the Cochrane Library were searched for prospective studies published from 1 January 1995 to 15 October 2016. Two types of meta-analyses were performed with a focus on the dose-response relationship using two stage generalised least squares regression.
resultsThe primary analysis exhibited a dose-response trend for all-cause dementia (ACD), Alzheimer's disease (AD) but not for vascular dementia (VD). In the dose-response analysis, either ACD (p
conclusionsWe have reported, for the first time, the dose-response relationship between LTPA and dementia, further supporting the international PA guideline from the standpoint of dementia prevention.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.