Evidence map›Paper›PMID 29061566›Full record

SynthesisCirculation2017

Thyroid Function Within the Normal Range, Subclinical Hypothyroidism, and the Risk of Atrial Fibrillation.

Christine Baumgartner, Bruno R da Costa, Tinh-Hai Collet, Martin Feller, Carmen Floriani, Douglas C Bauer, Anne R Cappola, Susan R Heckbert, Graziano Ceresini, Jacobijn Gussekloo and 17 more

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Circulation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 16 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 16 syntheses or guidelines pooled it, 242 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Thyroid Function and Dysfunction in Relation to 16 Cardiovascular Diseases.Circulation. Genomic and precision medicine · 2019
    Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Trial
  18. Trial
  19. Article
  20. Article

75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 18 institutions in 11 countries.

Christine BaumgartnerDepartment of General Internal Medicine, Inselspital, Bern University Hospital, (C.B., M.F., C.F., D.A., N.R.).
Bruno R da CostaInstitute of Primary Health Care (BIHAM) (B.R.d.C., M.F., N.R.).
Tinh-Hai ColletService of Endocrinology, Diabetes and Metabolism, University Hospital of Lausanne, Switzerland (T.-H.C.).
Martin FellerDepartment of General Internal Medicine, Inselspital, Bern University Hospital, (C.B., M.F., C.F., D.A., N.R.).
Carmen FlorianiDepartment of General Internal Medicine, Inselspital, Bern University Hospital, (C.B., M.F., C.F., D.A., N.R.).
Douglas C BauerDepartments of Medicine and Epidemiology and Biostatistics, University of California, San Francisco (D.C.B.).
Anne R CappolaUniversity of Pennsylvania School of Medicine, Philadelphia (A.R.C.).
Susan R HeckbertDepartment of Epidemiology, University of Washington, Seattle (S.R.H.).
Graziano CeresiniDepartment of Clinical and Experimental Medicine, Geriatric Endocrine Unit, University Hospital of Parma, Italy (G.C.).
Jacobijn GusseklooDepartment of Public Health and Primary Care, and Department of Gerontology and Geriatrics (J.G.).
Wendy P J den ElzenDepartment of Clinical Chemistry and Laboratory Medicine (W.P.J.d.E.).
Robin P PeetersLeiden University Medical Center, The Netherlands; Departments of Internal Medicine and Epidemiology (R.P.P.).
Robert LubenErasmus Medical Center, Rotterdam, The Netherlands; Department of Public Health and Primary Care, University of Cambridge, Addenbrooke's Hospital, United Kingdom (R.L., K.-T.K.).
Henry VölzkeInstitute for Community Medicine, Clinical-Epidemiological Research (H.V.).
Marcus DörrDepartment of Internal Medicine (M.D.).
John P WalshUniversity Medicine Greifswald, Germany, and German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Germany; School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia (J.P.W.).
Alexandra BremnerSchool of Population Health, University of Western Australia, Crawley, Australia (A.B.).
Massimo IacovielloCardiology Unit, Department of Emergency and Organ Transplantation, University of Bari, Italy (M.I.).
Peter MacfarlaneInstitute of Health and Wellbeing (P.M.).
Jan HeeringaDepartment of Epidemiology and Biostatistics (J.H.).
David J StottInstitute of Cardiovascular and Medical Sciences, (D.J.S.).
Rudi G J WestendorpUniversity of Glasgow, United Kingdom; Department of Public Health and Center for Healthy Aging, University of Copenhagen, Denmark (R.G.J.W.).
Kay-Tee KhawErasmus Medical Center, Rotterdam, The Netherlands; Department of Public Health and Primary Care, University of Cambridge, Addenbrooke's Hospital, United Kingdom (R.L., K.-T.K.).
Jared W MagnaniHeart and Vascular Institute, Department of Medicine, University of Pittsburgh, PA (J.W.M.).
Drahomir AujeskyDepartment of General Internal Medicine, Inselspital, Bern University Hospital, (C.B., M.F., C.F., D.A., N.R.).
Nicolas RodondiDepartment of General Internal Medicine, Inselspital, Bern University Hospital, (C.B., M.F., C.F., D.A., N.R.) Nicolas.Rodondi@insel.ch.
Thyroid Studies Collaboration
University Hospital of Bern · CHAddenbrooke's Hospital · GBThe University of Western Australia · AUBritish Geriatrics Society · GBCancer Research And Biostatistics · USCardiovascular Institute of the South · USInstitute for Community Health · USJ.P. Morgan · GBLeiden University Medical Center · NLManchester Health and Wellbeing Service · GBSt. Michael's Hospital · CAUniversity of Bari Aldo Moro · ITUniversity of California, San Francisco · USUniversity of Glasgow · GBUniversity of Lausanne · CHUniversity of Parma · ITUniversity of Pennsylvania · USUniversity of Washington · US

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
Oregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7M
Outcomes of Sleep Disorders in Older MenR01HL071194 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI STONE, KATIE L · 2003 to 2013
$12.2M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
Osteoporotic Fractures in Men (MrOS) - San Francisco Coordinating CenterU01AR066160 · NIAMS · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON · 2013 to 2017
$9.3M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
CHS Events Follow-up StudyR01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2009 to 2014
$6.3M
Osteoporotic Fractures in Men (MrOS) - MinneapolisU01AG042145 · NIA · UNIVERSITY OF MINNESOTA · PI ENSRUD, KRISTINE · 2013 to 2019
$5.3M
Osteporotic Fractures in Men (MrOS)- Admin CenterU01AG027810 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2017
$5.1M
CHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6M
Peripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5M
Osteoporotic Fractures in Men (MrOS) - PortlandU01AG042124 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2013 to 2019
$3.0M
Cancer Research UK 14136Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MR/N003284/1NCATS NIH HHS UL1 TR000128NCATS NIH HHS UL1 TR002369NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL070837NHLBI NIH HHS R01 HL070838NHLBI NIH HHS R01 HL070839NHLBI NIH HHS R01 HL070841NHLBI NIH HHS R01 HL070842NHLBI NIH HHS R01 HL070847NHLBI NIH HHS R01 HL070848NHLBI NIH HHS R01 HL071194NHLBI NIH HHS R01 HL080295NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIAMS NIH HHS K24 AR051895NIAMS NIH HHS U01 AR066160NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG028050NIA NIH HHS U01 AG027810NIA NIH HHS U01 AG042124NIA NIH HHS U01 AG042139NIA NIH HHS U01 AG042140NIA NIH HHS U01 AG042143NIA NIH HHS U01 AG042145NIA NIH HHS U01 AG042168NINR NIH HHS R01 NR012459
6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) is a highly prevalent disorder leading to heart failure, stroke, and death. Enhanced understanding of modifiable risk factors may yield opportunities for prevention. The risk of AF is increased in subclinical hyperthyroidism, but it is uncertain whether variations in thyroid function within the normal range or subclinical hypothyroidism are also associated with AF.

methodsWe conducted a systematic review and obtained individual participant data from prospective cohort studies that measured thyroid function at baseline and assessed incident AF. Studies were identified from MEDLINE and EMBASE databases from inception to July 27, 2016. The euthyroid state was defined as thyroid-stimulating hormone (TSH) 0.45 to 4.49 mIU/L, and subclinical hypothyroidism as TSH 4.5 to 19.9 mIU/L with free thyroxine (fT4) levels within reference range. The association of TSH levels in the euthyroid and subclinical hypothyroid range with incident AF was examined by using Cox proportional hazards models. In euthyroid participants, we additionally examined the association between fT4 levels and incident AF.

resultsOf 30 085 participants from 11 cohorts (278 955 person-years of follow-up), 1958 (6.5%) had subclinical hypothyroidism and 2574 individuals (8.6%) developed AF during follow-up. TSH at baseline was not significantly associated with incident AF in euthyroid participants or those with subclinical hypothyroidism. Higher fT4 levels at baseline in euthyroid individuals were associated with increased AF risk in age- and sex-adjusted analyses (hazard ratio, 1.45; 95% confidence interval, 1.26-1.66, for the highest quartile versus the lowest quartile of fT4;

conclusionsIn euthyroid individuals, higher circulating fT4 levels, but not TSH levels, are associated with increased risk of incident AF.

Indexed as

AdultAgedAged, 80 and overAsymptomatic DiseasesAtrial FibrillationBiomarkersChi-Square DistributionFemaleHumansHypothyroidismIncidenceMaleMiddle AgedPredictive Value of TestsPrognosisProportional Hazards ModelsBiomarkersThyrotropinThyroxineatrial fibrillationhypothyroidismthyrotropinthyroxine

Identifiers

PMID29061566
PMCPMC5705446
OpenAlexW2765818361

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.