Evidence map›Paper›PMID 29061560›Full record

ArticleCancer prevention research (Philadelphia, Pa.)2018

Bitter Melon Prevents the Development of 4-NQO-Induced Oral Squamous Cell Carcinoma in an Immunocompetent Mouse Model by Modulating Immune Signaling.

Subhayan Sur, Robert Steele, Rajeev Aurora, Mark Varvares, Katherine E Schwetye, Ratna B Ray

Open access · hybridAbstract read
In one paragraph

Article in Cancer prevention research (Philadelphia, Pa.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Antioxidants (Basel, Switzerland) · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Nutraceutical Potential of Bitter Melon (Current issues in molecular biology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Bioactives ofMolecules (Basel, Switzerland) · 2022
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Diverse roles of bitter melon (Journal of cancer metastasis and treatment · 2021
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Subhayan SurDepartment of Pathology, Saint Louis University, St. Louis, Missouri.
Robert SteeleDepartment of Pathology, Saint Louis University, St. Louis, Missouri.
Rajeev AuroraDepartment of Molecular Microbiology & Immunology, Saint Louis University, St. Louis, Missouri.
Mark VarvaresCancer Center, Saint Louis University, St. Louis, Missouri.
Katherine E SchwetyeDepartment of Pathology, Saint Louis University, St. Louis, Missouri.
Ratna B RayDepartment of Pathology, Saint Louis University, St. Louis, Missouri. rayrb@slu.edu.
University of Missouri–St. Louis · USSaint Louis University · ESSaint Louis University · US

Funding

Mechanistic Insights of BME mediated inhibition of head and neck cancer growthR01DE025141 · NIDCR · SAINT LOUIS UNIVERSITY · PI Ratna B. Ray · 2015 to 2026
$4.2M
THE UBIQUITIN PATHWAY IN CORNEAL SCARRINGR01EY024942 · NEI · UPSTATE MEDICAL UNIVERSITY · PI AUDREY M BERNSTEIN · 2015 to 2026
$3.1M
NEI NIH HHS R01 EY024942NIDCR NIH HHS R01 DE025141
6 · The paper itself

Abstract

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and tobacco is one of the most common factors for HNSCC of the oral cavity. We have previously observed that bitter melon (

Indexed as

Disease Models, Animal4-Nitroquinoline-1-oxideAnimalsApoptosisCarcinogensCarcinoma, Squamous CellCell ProliferationImmune System PhenomenaMiceMice, Inbred C57BLMice, SCIDMomordica charantiaMouth NeoplasmsPlant ExtractsTumor Cells, Cultured4-Nitroquinoline-1-oxideCarcinogensPlant Extracts

Identifiers

PMID29061560
PMCPMC5882513
OpenAlexW2765852973

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.