Evidence map›Paper›PMID 29060525›Full record

ArticleAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference2017

ARFI variance of acceleration (VoA) for noninvasive characterization of human carotid plaques in vivo.

Gabriela Torres, Tomasz J Czernuszewicz, Jonathon W Homeister, Mark A Farber, Caterina M Gallippi

Abstract read
In one paragraph

Article in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Comparison of Filtering Methods for Calculating ARFI log(VoA) to Delineate Carotid Plaque Features, In Vivo.IEEE open journal of ultrasonics, ferroelectrics, and frequency control · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gabriela Torres
Tomasz J Czernuszewicz
Jonathon W Homeister
Mark A Farber
Caterina M Gallippi

Funding

Pre-doctoral Training Program in Integrative Vascular BiologyT32HL069768 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Christopher P. Mack · 2002 to 2026
$9.7M
Transcutaneous ARFI Ultrasound for Differentiating Carotid Plaque with High Stroke RiskR01HL092944 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GALLIPPI, CATERINA M · 2009 to 2022
$5.5M
VisR Ultrasound for Noninvasively Monitoring Renal Allograft HealthR01DK107740 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Caterina M Gallippi · 2016 to 2026
$5.2M
Independent Scientist: ARFI and RWI Ultrasound for Improved Atherosclerosis ImagiK02HL105659 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GALLIPPI, CATERINA M · 2010 to 2014
$509k
NHLBI NIH HHS K02 HL105659NHLBI NIH HHS R01 HL092944NHLBI NIH HHS T32 HL069768NIDDK NIH HHS R01 DK107740
6 · The paper itself

Abstract

Rather than degree of stenosis, assessing plaque structure and composition is relevant to discerning risk for plaque rupture with downstream ischemic event. The structure and composition of carotid plaque has been assessed noninvasively using Acoustic Radiation Force Impulse (ARFI) ultrasound imaging. In particular, ARFI-derived peak displacement (PD) estimations have been demonstrated for discriminating soft (lipid rich necrotic core (LRNC) or intraplaque hemorrhage (IPH)) from stiff (collagen (COL) or calcium (CAL)) plaque features; however, PD did not differentiate LRNC from IPH or COL from CAL. The purpose of this study is to evaluate a new ARFI-based measurement, the variance of acceleration (VoA), for differentiating among soft and stiff plaque components. Both PD and VoA results were obtained in vivo for a human carotid plaque acquired in a previous study and matched to a histological standard analyzed by a pathologist. With VoA, plaque feature contrast was increased by an average of 60% in comparison to PD.

Indexed as

Carotid StenosisCarotid ArteriesHemorrhageHumansNecrosisPlaque, AtheroscleroticUltrasonography

Identifiers

PMID29060525
PMCPMC7952012

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.