Evidence map›Paper›PMID 29059314›Full record

ArticleInvestigative ophthalmology & visual science2017

Foveal and Peripapillary Vascular Decrement in Migraine With Aura Demonstrated by Optical Coherence Tomography Angiography.

Melinda Y Chang, Nopasak Phasukkijwatana, Sean Garrity, Stacy L Pineles, Mansour Rahimi, David Sarraf, Mollie Johnston, Andrew Charles, Anthony C Arnold

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Investigative ophthalmology & visual science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Retinal nerve fiber layer changes in migraine: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Pooled it
  3. Article
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  10. Review
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  14. Review
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  17. Evaluation of retinal vessel density and choriocapillaris flow in migraine patients with and without aura.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020
    Article
  18. Effects of iron deficiency anemia on peripapillary and macular vessel density determined using optical coherence tomography angiography on children.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020
    Article
  19. Observational
  20. Migraine Aura: Updates in Pathophysiology and Management.Current neurology and neuroscience reports · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Melinda Y ChangStein Eye Institute, University of California, Los Angeles, California, United States.
Nopasak PhasukkijwatanaStein Eye Institute, University of California, Los Angeles, California, United States.
Sean GarrityStein Eye Institute, University of California, Los Angeles, California, United States.
Stacy L PinelesStein Eye Institute, University of California, Los Angeles, California, United States.
Mansour RahimiStein Eye Institute, University of California, Los Angeles, California, United States.
David SarrafStein Eye Institute, University of California, Los Angeles, California, United States.
Mollie JohnstonDepartment of Neurology, University of California, Los Angeles, California, United States.
Andrew CharlesDepartment of Neurology, University of California, Los Angeles, California, United States.
Anthony C ArnoldStein Eye Institute, University of California, Los Angeles, California, United States.
University of California, Los Angeles · USDoheny Eye Institute · USSiriraj Hospital · TH

Funding

Binocular Summation in StrabismusK23EY021762 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PINELES, STACY · 2011 to 2015
$1.1M
NEI NIH HHS K23 EY021762
6 · The paper itself

Abstract

Purpose: Migraine, particularly with aura, has been associated with ocular and systemic ischemic complications, but there are limited data on the ocular vasculature in migraine. We used optical coherence tomography angiography (OCTA) to assess perfusion of the macula and optic nerve in migraine patients, with (MA) and without (MO) aura, compared to healthy controls (HC). Methods: We recruited 15 MA (mean age 42 years), 12 MO (mean age 46 years), and 22 HC (mean age 39 years) participants from neurology and neuro-ophthalmology clinics. Participants underwent optical coherence tomography and 3 × 3 mm OCTA of the macula and optic nerve. Foveal avascular zone area was automatically measured using AngioVue software, and vessel density was calculated as blood vessel length divided by scan area (mm-1) after skeletonization of OCTA images. Results: On macular OCTA, MA participants had an enlarged foveal avascular zone area when compared with HC (0.300 ± 0.019 vs. 0.220 ± 0.066 mm2, P = 0.006). In addition, superficial foveal vessel density was decreased in MA participants when compared with MO participants (7.8 ± 0.31 vs. 9.3 ± 0.44, P = 0.04) and HC (7.8 ± 0.31 vs. 9.4 ± 0.21 mm-1, P = 0.002). On optic nerve OCTA, the MA participants had reduced superior peripapillary vessel density when compared with the MO participants (12.0 ± 0.45 vs. 14.0 ± 0.38 mm-1, P = 0.031) and HC (12.0 ± 0.45 vs. 14.1 ± 0.53 mm-1, P = 0.035). There were no significant differences between the MO and HC groups. Conclusions: Migraine with, but not without, aura was associated with foveal and peripapillary vascular decrements, which may possibly mediate increased risk of ocular and systemic vascular complications in these patients. OCTA could potentially be useful as a biomarker for migraine with aura.

Indexed as

AdolescentAdultComputed Tomography AngiographyFemaleFovea CentralisHealthy VolunteersHumansMaleMiddle AgedMigraine with AuraMigraine without AuraOptic DiskTomography, Optical CoherenceYoung Adult

Identifiers

PMID29059314
PMCPMC5656414
OpenAlexW2748897784

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.