Observational studyClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017
Glycemic Control and the Prevalence of Tuberculosis Infection: A Population-based Observational Study.
Observational study in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Diabetes mellitus and latent tuberculosis infection: an updated meta-analysis and systematic review.BMC infectious diseases · 2023Pooled it
- The Association Between Diabetes Mellitus and the Risk of Latent Tuberculosis Infection: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2022Pooled it
- Poor glycemic control among people with diabetes mellitus is associated with tuberculosis infection: a cross-sectional study in Nepal.BMC infectious diseases · 2025Article
- Glycemic Profile and Clinical Treatment in Patients with Diabetes Mellitus-Tuberculosis: An Update Scoping Review.Journal of multidisciplinary healthcare · 2025Review
- Latent tuberculosis infection and diagnostic performance of the tuberculin skin test among type 2 diabetics in Sana'a city, Yemen.BMC infectious diseases · 2024Article
- Longitudinal trends in glycated hemoglobin during and after tuberculosis treatment.Diabetes research and clinical practice · 2023Article
- Gut microbiota composition can reflect immune responses of latent tuberculosis infection in patients with poorly controlled diabetes.Respiratory research · 2023Article
- The Impact of Diabetes and Prediabetes on Prevalence ofOpen forum infectious diseases · 2022Article
- Increased Risk of Incident Diabetes Among Individuals With Latent Tuberculosis Infection.Diabetes care · 2022Article
- Prevalence of latent tuberculosis infection among participants of the national LTBI screening program in South Korea - A problem of low coverage rate with current LTBI strategy.Frontiers in public health · 2022Article
- The association between diabetes status and latent-TB IGRA levels from a cross-sectional study in eastern China.Frontiers in cellular and infection microbiology · 2022Article
- Glycemic control and the risk of tuberculosis in patients with diabetes: A cohort study in a Mediterranean city.Frontiers in public health · 2022Article
- Lifestyle changes and risk of tuberculosis in patients with type 2 diabetes mellitus: A nationwide cohort study.Frontiers in endocrinology · 2022Article
- The role of pathogens in diabetes pathogenesis and the potential of immunoproteomics as a diagnostic and prognostic tool.Frontiers in microbiology · 2022Review
- Identifying Priorities for Testing and Treatment of Latent Tuberculosis Infection in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Completion Rate and Safety of Programmatic Screening and Treatment for Latent Tuberculosis Infection in Elderly Patients With Poorly Controlled Diabetic Mellitus: A Prospective Multicenter Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Diabetes Status and Association With Risk of Tuberculosis Among Korean Adults.JAMA network open · 2021Article
- Latent tuberculosis infection among patients with and without type-2 diabetes mellitus: results from a hospital case-control study in Atlanta.BMC research notes · 2021Article
- A risk score for prediction of poor treatment outcomes among tuberculosis patients with diagnosed diabetes mellitus from eastern China.Scientific reports · 2021Article
- Association between latent tuberculosis and ischemic heart disease: a hospital-based cross-sectional study from Saudi Arabia.The Pan African medical journal · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral cohort studies demonstrate that diabetics are at increased risk for active tuberculosis, and poor glycemic control may exacerbate this risk. A higher prevalence of tuberculosis infection at baseline among diabetics may partially explain these results; however, no population-based studies have investigated this association. Furthermore, whether glycemic control modifies the relationship between diabetes and tuberculosis infection, as it does with active tuberculosis, is unknown.
methodsDiabetics were diagnosed through physician evaluation and using 3 laboratory tests including hemoglobin A1C (HbA1C), fasting plasma glucose (FPG), or 2-hour plasma glucose (PG). Tuberculosis infection was diagnosed through tuberculin skin tests, and glycemic control was assessed linearly and categorically using recommended targets.
resultsAmong 4215 participants, the prevalence of tuberculosis infection was 4.1%, 5.5%, and 7.6% in nondiabetic, prediabetic, and diabetic participants (Ptrend = .012). In multivariate analysis, diabetes was associated with tuberculosis infection (adjusted odds ratio [AOR], 1.5; 95% confidence interval [CI], 1.0-2.2). Compared to nondiabetics, diabetics who were undiagnosed (AOR, 2.2 and 1.2 in diagnosed diabetics), FPG >130 mg/dL (AOR, 2.6 and 1.3 in diabetics with FPG ≤130 mg/dL), or not on insulin (AOR, 1.7 and 0.8 in diabetics on insulin) had elevated tuberculosis infection rates. In a linear dose-response analysis, increasing values of FPG (AOR, 1.02 per 1-mg/dL; 95% CI, 1.01-1.03), PG (AOR, 1.02 per 1-mg/dL; 95% CI, 1.01-1.04), and HbA1C (AOR, 1.13 per 1%; 95% CI, 1.04-1.22) all predicted tuberculosis infection.
conclusionsOur results suggest glycemic control may modify the relationship between tuberculosis infection and diabetes.
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