ArticlePloS one2017
Clock-dependent and system-driven oscillators interact in the suprachiasmatic nuclei to pace mammalian circadian rhythms.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- A minimal model of peripheral clocks reveals differential circadian re-entrainment in aging.Chaos (Woodbury, N.Y.) · 2023Article
- A Journey in the Brain's Clock: In Vivo Veritas?Biology · 2023Review
- Difference of cardiac rehabilitation in the morning or evening on indexes of left ventricular andAnnals of medicine and surgery (2012) · 2023Article
- STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses.Cell metabolism · 2022Article
- Aging Affects the Capacity of Photoperiodic Adaptation Downstream from the Central Molecular Clock.Journal of biological rhythms · 2020Article
- Observational
- Molecular and Cellular Networks in The Suprachiasmatic Nuclei.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circadian clocks drive biological rhythms with a period of approximately 24 hours and keep in time with the outside world through daily resetting by environmental cues. While this external entrainment has been extensively investigated in the suprachiasmatic nuclei (SCN), the role of internal systemic rhythms, including daily fluctuations in core temperature or circulating hormones remains debated. Here, we show that lactating mice, which exhibit dampened systemic rhythms, possess normal molecular clockwork but impaired rhythms in both heat shock response gene expression and electrophysiological output in their SCN. This suggests that body rhythms regulate SCN activity downstream of the clock. Mathematical modeling predicts that systemic feedback upon the SCN functions as an internal oscillator that accounts for in vivo and ex vivo observations. Thus we are able to propose a new bottom-up hierarchical organization of circadian timekeeping in mammals, based on the interaction in the SCN between clock-dependent and system-driven oscillators.
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