ArticlePLoS neglected tropical diseases2017
Strongyloides stercoralis is associated with significant morbidity in rural Cambodia, including stunting in children.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Systematic review to evaluate a potential association between helminth infection and physical stunting in children.Parasites & vectors · 2022Pooled it
- A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: Is it time to reconsider the current contraindication?PLoS neglected tropical diseases · 2021Pooled it
- Strongyloidiasis in Africa: Systematic Review and Meta-Analysis on Prevalence, Diagnostic Methods, and Study Settings.BioMed research international · 2020Pooled it
- Morbidity Associated with ChronicThe American journal of tropical medicine and hygiene · 2019Pooled it
- Clinical evaluation for morbidity associated with soil-transmitted helminth infection in school-age children on Pemba Island, Tanzania.PLoS neglected tropical diseases · 2019Trial
- Transgenesis and targeted mutagenesis in the human-parasitic nematodeFrontiers in parasitology · 2026Review
- Seroprevalence ofJournal of parasitology research · 2026Article
- Serology-Based Screening and Prevalence of Schistosomiasis, Strongyloidiasis, and Chagas Disease in Migrants Living with HIV: Results from a 10-Year Retrospective Cohort in an Italian Tertiary Healthcare Center.Tropical medicine and infectious disease · 2025Article
- Widespread Soil-Transmitted Parasitic Contamination in Raw Vegetables at Fresh Markets in the Inner Zone of Bangkok: Findings from a Cross-Sectional Study.The American journal of tropical medicine and hygiene · 2025Article
- Co-infection prevalence of helminths and associated risk factors among schoolchildren in the Lake Tana Basin, Northwest Ethiopia.BMC infectious diseases · 2025Article
- Dopamine signaling drives skin invasion by human-infective nematodes.Nature communications · 2025Article
- Epidemiology of Strongyloides stercoralis and Opisthorchis viverrini infections in northern and northeastern Thailand: Insights from urine-ELISA surveys.Parasitology research · 2024Article
- Artificial intelligence-based digital pathology for the detection and quantification of soil-transmitted helminths eggs.PLoS neglected tropical diseases · 2024Article
- Strongyloidiasis.Nature reviews. Disease primers · 2024Review
- Human strongyloidiasis: complexities and pathways forward.Clinical microbiology reviews · 2023Review
- Seroepidemiology of Strongyloides spp. Infection in Balimo, Western Province, Papua New Guinea.The American journal of tropical medicine and hygiene · 2023Article
- Prevalence of Strongyloides stercoralis infection and associated clinical symptoms among schoolchildren living in different altitudes of Amhara National Regional State, northwest Ethiopia.PLoS neglected tropical diseases · 2022Article
- Article
- Prevalence and risk factors of strongyloidiasis among schoolchildren in Sabach Sanjal and Upper Badibou districts in the North Bank East Region of The Gambia.Parasite epidemiology and control · 2021Article
- Strongyloidiasis in Children Outside the Tropics: Do We Need to Increase Awareness?Microorganisms · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStrongyloides stercoralis is a soil-transmitted nematode that can replicate within its host, leading to long-lasting and potentially fatal infections. It is ubiquitous and highly prevalent in Cambodia. The extent of morbidity associated with S. stercoralis infection is difficult to assess due to the broad spectrum of symptoms and, thus, remains uncertain. METHODOLOGY/PRINCIPAL
findingsClinical signs were compared among S. stercoralis infected vs. non-infected participants in a cross-sectional survey conducted in 2012 in eight villages of Northern Cambodia, and before and after treatment with a single oral dose of ivermectin (200μg/kg BW) among participants harboring S. stercoralis. Growth retardation among schoolchildren and adolescents was assessed using height-for-age and thinness using body mass index-for-age. S. stercoralis prevalence was 31.1% among 2,744 participants. Urticaria (55% vs. 47%, OR: 1.4, 95% CI: 1.1-1.6) and itching (52% vs. 48%, OR: 1.2, 95% CI: 1.0-1.4) were more frequently reported by infected participants. Gastrointestinal, dermatological, and respiratory symptoms were less prevalent in 103 mono-infected participants after treatment. Urticaria (66% vs. 11%, OR: 0.03, 95% CI: 0.01-0.1) and abdominal pain (81 vs. 27%, OR: 0.07, 95% CI: 0.02-0.2) mostly resolved by treatment. S. stercoralis infection was associated with stunting, with 2.5-fold higher odds in case of heavy infection. CONCLUSIONS/SIGNIFICANCE: The morbidity associated with S. stercoralis confirmed the importance of gastrointestinal and dermatological symptoms unrelated to parasite load, and long-term chronic effects when associated with malnutrition. The combination of high prevalence and morbidity calls for the integration of S. stercoralis into ongoing STH control measures in Cambodia.
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