Evidence map›Paper›PMID 29059190›Full record

Trial reportPLoS neglected tropical diseases2017

Cluster randomized trial comparing school-based mass drug administration schedules in areas of western Kenya with moderate initial prevalence of Schistosoma mansoni infections.

Diana M S Karanja, Emmy K Awino, Ryan E Wiegand, Edward Okoth, Bernard O Abudho, Pauline N M Mwinzi, Susan P Montgomery, W Evan Secor

Open access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  10. Comparison of the Impact of Different Mass Drug Administration Strategies on Infection withThe American journal of tropical medicine and hygiene · 2018
    Trial
  11. Article
  12. Development of prediction models to identify hotspots of schistosomiasis in endemic regions to guide mass drug administration.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Review
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  15. Article
  16. Article
  17. When Should the Emphasis on Schistosomiasis Control Move to Elimination?Tropical medicine and infectious disease · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Diana M S KaranjaNeglected Tropical Diseases Branch, Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Emmy K AwinoNeglected Tropical Diseases Branch, Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Ryan E WiegandDivision of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
Edward OkothNeglected Tropical Diseases Branch, Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Bernard O AbudhoNeglected Tropical Diseases Branch, Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Pauline N M MwinziNeglected Tropical Diseases Branch, Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Susan P MontgomeryDivision of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
W Evan SecorDivision of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.ORCID http://orcid.org/0000-0003-0584-5961
Kenya Medical Research Institute · KECenters for Disease Control and Prevention · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMass drug administration (MDA) using praziquantel is the WHO-recommended approach for control of schistosomiasis. However, few studies have compared the impact of different schedules of MDA on the resultant infection levels. We wished to evaluate whether annual MDA was more effective than less frequent treatments for reducing community-level prevalence and intensity of Schistosoma mansoni infections.

methodsWe performed a cluster randomized trial (ISRCTN 14849830) of 3 different MDA frequencies over a 5 year period in 75 villages with moderate (10%-24%) initial prevalence of S. mansoni in school children in western Kenya. Praziquantel was distributed by school teachers to students either annually, the first 2 years, or every other year over a 4 year period. Prevalence and intensity of infection were measured by stool examination in 9-12 year old students using the Kato-Katz method at baseline, each treatment year, and for the final evaluation at year 5. S. mansoni prevalence and intensity were also measured in first year students at baseline and year 5.

resultsTwenty-five schools were randomly assigned to each arm. S. mansoni prevalence and infection intensity in 9-12 year old students significantly decreased within each arm from baseline to year 5 but there were no differences between arms. There were no differences in infection levels in first year students either within or between arms.

conclusionsStrategies employing 2 or 4 rounds of MDA had a similar impact in schools with moderate initial prevalence, suggesting that schistosomiasis control can be sustained by school-based MDA, even if provided only every other year.

Indexed as

Drug Administration ScheduleAnimalsChildFecesFemaleHumansKenyaMalePraziquantelPrevalenceSchistosoma mansoniSchistosomiasis mansoniSchistosomicidesSchoolsStudentsTime FactorsPraziquantelSchistosomicides

Identifiers

PMID29059190
PMCPMC5667887
OpenAlexW2766403282

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.