Trial reportPLoS neglected tropical diseases2017
Lymphatic pathology in asymptomatic and symptomatic children with Wuchereria bancrofti infection in children from Odisha, India and its reversal with DEC and albendazole treatment.
Trial report in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Prevalence, probability, and characteristics of malaria and filariasis co-infections: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2022Pooled it
- Albendazole alone or in combination with microfilaricidal drugs for lymphatic filariasis.The Cochrane database of systematic reviews · 2019Pooled it
- Haematological and biochemical profiling combined with HRAMS-based metabolomics reveals the potential biomarkers ofRSC advances · 2026Article
- Frequency and Distribution of Lymphatic Filariasis in Somalia: A Single-Center Experience.Journal of tropical medicine · 2026Article
- From defense to disease: the multifaceted role of lymphatics during infection.Journal of immunology (Baltimore, Md. : 1950) · 2025Review
- Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update.The Korean journal of parasitology · 2021Review
- Tetracyclines improve experimental lymphatic filariasis pathology by disrupting interleukin-4 receptor-mediated lymphangiogenesis.The Journal of clinical investigation · 2021Article
- Nontraumatic chylothorax secondary to lymphoma and filariasis.Journal of surgical case reports · 2020Article
- Frequency and Clinical Significance of Localized Adverse Events following Mass Drug Administration for Lymphatic Filariasis in an Endemic Area in South India.The American journal of tropical medicine and hygiene · 2020Article
- Advances in Antiwolbachial Drug Discovery for Treatment of Parasitic Filarial Worm Infections.Tropical medicine and infectious disease · 2019Review
- Preventive chemotherapy reverses covert, lymphatic-associated tissue change in young people with lymphatic filariasis in Myanmar.Tropical medicine & international health : TM & IH · 2019Article
- Elimination of lymphatic filariasis in South East Asia.BMJ (Clinical research ed.) · 2019Article
- Filarial infection during pregnancy has profound consequences on immune response and disease outcome in children: A birth cohort study.PLoS neglected tropical diseases · 2018Article
- Brugia malayi infection in ferrets - A small mammal model of lymphatic filariasis.PLoS neglected tropical diseases · 2018Article
- Rest/stress intradermal lymphoscintigraphy in diagnosis of lipedema.World journal of nuclear medicineArticle
- Revisiting Koch's postulates: A tailored approach for clinical parasitology.Tropical parasitologyArticle
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Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOnce interruption of transmission of lymphatic filariasis is achieved, morbidity prevention and management becomes more important. A study in Brugia malayi filariasis from India has shown sub-clinical lymphatic pathology with potential reversibility. We studied a Wuchereria bancrofti infected population, the major contributor to LF globally.
methodsChildren aged 5-18 years from Odisha, India were screened for W. bancrofti infection and disease. 102 infected children, 50 with filarial disease and 52 without symptoms were investigated by lymphoscintigraphy and then randomized to receive a supervised single oral dose of DEC and albendazole which was repeated either annually or semi-annually. The lymphatic pathology was evaluated six monthly for two years.
findingsBaseline lymphoscintigraphy showed abnormality in lower limb lymphatics in 80% of symptomatic (40/50) and 63·5% (33/52) of asymptomatic children. Progressive improvement in baseline pathology was seen in 70·8, 87·3, 98·6, and 98·6% of cases at 6, 12, 18, and 24 months follow up, while in 4·2, 22·5, 47·9 and 64·8%, pathology reverted to normal. This was independent of age (p = 0·27), symptomatic status (p = 0·57) and semi-annual/bi-annual dosing (p = 0·46). Six of eleven cases showed clinical reduction in lymphedema of legs.
interpretationA significant proportion of a young W. bancrofti infected population exhibited lymphatic pathology which was reversible with annual dosage of DEC and albendazole. This provides evidence for morbidity prevention & treatment of early lymphedema. It can also be used as a tool to improve community compliance during mass drug administration.
trial registrationClinicalTrials.gov No CTRI/2013/10/004121.
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