Evidence map›Paper›PMID 29059156›Full record

ArticleOncogene2018

Extracellular matrix protein 1 promotes cell metastasis and glucose metabolism by inducing integrin β4/FAK/SOX2/HIF-1α signaling pathway in gastric cancer.

L Gan, J Meng, M Xu, M Liu, Y Qi, C Tan, Y Wang, P Zhang, W Weng, W Sheng and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 2 syntheses or guidelines pooled it, 167 citations in OpenAlex.

  1. Pooled it
  2. Biomarkers of tumor invasiveness in proteomics (Review).International journal of oncology · 2020
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Halofuginone is a Molecular Glue Degrader of Integrin β4.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Exploring the interactions of integrins and CEACAM6 (Review).Experimental and therapeutic medicine · 2025
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

L GanCancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China.
J MengCancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China.
M XuDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
M LiuCancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China.
Y QiDepartment of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
C TanDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Y WangNanchang Medical College, Nanchang University, Nanchang, China.
P ZhangCancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China.
W WengDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
W ShengDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
M HuangDepartment of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Z WangCancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China.
Fudan University Shanghai Cancer Center · CNShanghai Medical College of Fudan University · CNNanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular matrix protein 1 (ECM1) is related to strong invasiveness and poor prognosis in major malignancies, but the underlying mechanism remains unknown. Here we aimed to elucidate the function of ECM1 on cell metastasis and glucose metabolism in gastric cancer (GC). The level of ECM1 in sera and tissues of patient with GC were positively correlated with tumor invasion and recurrence. Genetic manipulation of ECM1 expression affected cell metastasis and glucose metabolism in GC cell lines. Enhanced ECM1 expression facilitated gene expression levels associated with epithelial-mesenchymal transition (EMT) and glucose metabolism. Interestingly, our results indicated that ECM1 directly interacted with integrin β4 (ITGB4) and activated ITGB4/focal adhesion kinase (FAK)/glycogen synthase kinase 3β signaling pathway, which further induced the expression of transcription factor SOX2. Aberrant expression of SOX2 altered gene expression of EMT factors and glucose metabolism enzymes. Furthermore, SOX2 enhanced hypoxia-inducible factor α (HIF-1α) promoter activity to regulate glucose metabolism. The micro-positron emission tomography/computed tomography imaging of xenograft model showed that ECM1 substantially increased

Indexed as

AdenocarcinomaAnimalsApoptosisBiomarkers, TumorCase-Control StudiesCell MovementCell ProliferationExtracellular Matrix ProteinsFocal Adhesion Kinase 1Follow-Up StudiesGlucoseHumansHypoxia-Inducible Factor 1, alpha SubunitIntegrin beta4Lymphatic MetastasisMaleBiomarkers, TumorECM1 protein, humanExtracellular Matrix ProteinsFocal Adhesion Kinase 1GlucoseHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitIntegrin beta4PTK2 protein, humanSOX2 protein, humanSOXB1 Transcription Factors

Identifiers

PMID29059156
OpenAlexW2766590311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.