ReviewDermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]2018
Atypical Melanocytic Proliferations: A Review of the Literature.
Review in Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Long-Term Outcomes Support Utilization of 23-GEP in Clinically Ambiguous Melanocytic Neoplasms.The American Journal of dermatopathology · 2026Article
- Increased dendritic cell density and altered melanin patterns distinguish melanoma from Nevi on CRFF-OCT: A pilot study toward noninvasive diagnosis.Journal of the American Academy of Dermatology · 2026Article
- Non-Melanocytic Histopathological Clues for Melanoma Diagnosis: A Practical Review of Solar Elastosis, Stromal Regression, and Epidermal Reaction Patterns. Do Old-School Clues Still Matter?Dermatopathology (Basel, Switzerland) · 2026Review
- Histopathological Subtypes of Cutaneous Melanoma: Prognostic and Molecular Implications.Cureus · 2025Review
- A clinical impact study of dermatologists' use of diagnostic gene expression profile testing to guide patient management.Melanoma management · 2024Article
- Article
- The Implications of a Dermatopathologist's Report on Melanoma Diagnosis and Treatment.Life (Basel, Switzerland) · 2023Article
- In vivo reflectance confocal microscopy can detect the invasive component of lentigo maligna melanoma: Prospective analysis and case-control study.Journal of the European Academy of Dermatology and Venereology : JEADV · 2023Article
- Melanin Stacking Differences in Pigmented and Non-Pigmented Melanomas: Quantitative Differentiation between Pigmented and Non-Pigmented Melanomas Based on Light-Scattering Properties.Life (Basel, Switzerland) · 2023Article
- A Physician's Guide to the Use of Gene Expression Profile Ancillary Diagnostic Testing for Cutaneous Melanocytic Neoplasms.The Journal of clinical and aesthetic dermatology · 2023Review
- Response to Rigel et al.The Journal of investigative dermatology · 2022Article
- Melanoma and melanoma in-situ diagnosis after excision of atypical intraepidermal melanocytic proliferation: A retrospective cross-sectional analysis.Journal of the American Academy of Dermatology · 2019Observational
- Pediatric Melanoma Arising in a Background of Melanocytic Nevi.Indian dermatology online journalArticle
- Educational Case: Malignant Melanoma.Academic pathologyArticle
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Authors and funding
6 authors.
Funding
Abstract
backgroundAmbiguous histopathologic diagnoses represent a challenge for clinicians because of a lack of definitive diagnosis and related uncertainty about management.
objectiveTo review the literature on atypical melanocytic proliferations and detail synonymous terms, epidemiology, diagnostic work-up, histopathology, treatment, and prognosis.
methodsDatabases from PubMed and Web of Science were searched for articles related to atypical melanocytic proliferations.
resultsIntraepidermal melanocytic proliferations with features worrisome for possible melanoma in situ (MIS) are generally excised as for MIS. Reported rates of upstaging of such cases to invasive melanoma on review of the excision are very low. Because invasion, lymph node spread, and metastasis can occur in atypical melanocytic lesions with a thick intradermal component, these are often treated as for malignant melanoma.
conclusionBecause the diagnosis dictates treatment, it is incumbent to establish a diagnosis as definitive as possible, obtaining second or third opinions and using ancillary studies when appropriate. When the diagnosis remains uncertain, it is difficult to provide guidelines for treatment. Clinical care decisions for patients with an uncertain diagnosis are best done on a case-by-case basis weighing probabilities of adverse outcomes against potential benefits and risks from various treatment options.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.