ArticleInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences2018
Impact of histological thrombus composition on preinterventional thrombus migration in patients with acute occlusions of the middle cerebral artery.
Article in Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Correlation of imaging and histopathology of thrombi in acute ischemic stroke with etiology and outcome: a systematic review.Journal of neurointerventional surgery · 2017Pooled it
- Thrombus migration in patients with acute ischaemic stroke undergoing endovascular thrombectomy.Stroke and vascular neurology · 2024Trial
- Trial
- Is There a Relationship Between the Histopathological Features and Anatomical Locations of Thrombi Obtained During Endovascular Thrombectomy in Acute Ischemic Stroke and Its Comorbid Diseases?Diagnostics (Basel, Switzerland) · 2025Article
- Thrombus migration in intracranial large vessel occlusion: course, predictors, and impact on endovascular thrombectomy.Frontiers in neurology · 2025Article
- Bathing-Related Ischemic Stroke: Association between Stroke Subtype and Cerebral Small Vessel Disease.Journal of atherosclerosis and thrombosis · 2024Article
- Is Clot Composition Associated With Cause of Stroke? A Systematic Review and Meta-Analysis.Stroke (Hoboken, N.J.) · 2024Article
- Traditional Thrombus Composition and Related Endovascular Outcomes: Catching up with the Recent Evidence.Neurointervention · 2024Review
- Thrombus migration in ischemic stroke due to large vessel occlusion: a question of time.Journal of neurointerventional surgery · 2023Article
- Clinicopathologic Analysis of COVID-19 Associated Thrombi in the Setting of Large Vessel Occlusion: A Prospective Case-Control Study.Stroke (Hoboken, N.J.) · 2023Article
- Visualization of thrombus using iterative reconstruction and maximum intensity projection of thin-slice CT images.Neuroradiology · 2022Article
- Magnetic resonance imaging quantitative T2* mapping to predict the red blood cell content of in vivo thrombi retrieved from patients with large vessel occlusions in acute ischemic stroke.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2022Article
- A new aspiration device equipped with a hydro-separator for acute ischemic stroke due to challenging soft and stiff clots.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2022Article
- Histopathological Composition of Thrombus in Acute Ischemic Stroke May Vary Even Within the Same Patient: A Preliminary Study Examining Clots According to Their Area of Retrieval.Journal of neuroendovascular therapy · 2022Article
- Difference of Thrombus Location between Initial Noninvasive Vascular Image and First DSA Findings in Mechanical Thrombectomy for Intracranial Large Vessel Occlusion: Post Hoc Analysis of the SKIP Study.Neurologia medico-chirurgica · 2021Article
- Review
- Clot Composition Analysis as a Diagnostic Tool to Gain Insight into Ischemic Stroke Etiology: A Systematic Review.Journal of stroke · 2021Review
- Thrombus Structural Composition in Cardiovascular Disease.Arteriosclerosis, thrombosis, and vascular biology · 2021Review
- Novel Human Acute Ischemic Stroke Blood Clot Analogs for In Vitro Thrombectomy Testing.AJNR. American journal of neuroradiology · 2021Article
- Thrombus Composition and Efficacy of Thrombolysis and Thrombectomy in Acute Ischemic Stroke.Stroke · 2021Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose The occurrence of thrombus migration (TM) in middle cerebral arteries (MCAs) prior to mechanical thrombectomy (MT) in patients suffering from acute ischemic strokes is a crucial aspect as TM is associated with lower rates of complete reperfusion and worse clinical outcomes. In this study, we sought to clarify whether histological thrombus composition influences TM. Methods We included 64 patients with acute MCA occlusions who had undergone MT. In 11 of the cases (17.2%) we identified TM prior to the interventions. The extracted clots were collected and histologically examined. The hematoxylin and eosin-stained specimens were quantitatively analyzed in terms of the relative fractions of the main constituents (red and white blood cells and fibrin/platelets). The histologic patterns were correlated with the occurrence of TM. Results Patients in whom TM could be observed were more often treated in a drip-and-ship fashion (90.9% vs 41.5%, p = 0.003). Stroke etiology did not differ between migrated and stable thrombi. A weak tendency for higher RBC and lower F/P content could be observed in thrombi that had migrated when compared with stable thrombi (RBC: median 41% vs 37%, p = 0.022 and F/P: median 54% vs 57%, p = 0.024). When using a cut-off of 60% RBC content for the definition of RBC-rich thrombi, a higher portion of RBC-rich thrombi could be identified in the migrated group as opposed to the stable group (36.4% vs 5.7%, p = 0.003). Conclusion Preinterventional TM may be influenced by the histological thrombus composition in a way that RBC-rich thrombi are more prone to migrate.
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