ArticleDevelopmental psychology2018
NR3C1 methylation as a moderator of the effects of maternal support and stress on insecure attachment development.
Article in Developmental psychology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Review
- A narrative on the neurobiological roots of attachment-system functioning.Communications psychology · 2024Review
- Dopamine and Serotonin Transporter Genes Regulation in Highly Sensitive Individuals during Stressful Conditions: A Focus on Genetics and Epigenetics.Biomedicines · 2024Article
- Examining the Biological Impacts of Parent-Child Relationship Dynamics on Preschool-Aged Children who have Experienced Adversity.Developmental psychobiology · 2024Observational
- A perspective-based analysis of attachment from prenatal period to second year postnatal life.Frontiers in psychology · 2024Review
- The role of epigenetics in anxiety disorders.Molecular biology reports · 2023Review
- DNA methylation in blood cells is associated with cortisol levels in offspring of mothers who had prenatal post-traumatic stress disorder.Stress and health : journal of the International Society for the Investigation of Stress · 2022Article
- Attachment Representations in Children with and without Attention-Deficit/Hyperactivity Disorder (ADHD).Brain sciences · 2021Article
- Treatment Refractory Internalizing Behaviour Across Disorders: An Aetiological Model for Severe Emotion Dysregulation in Adolescence.Child psychiatry and human development · 2021Article
- Immune and Epigenetic Pathways Linking Childhood Adversity and Health Across the Lifespan.Frontiers in psychology · 2021Review
- Children's Attention to Mother and Adolescent Stress Moderate the Attachment-Depressive Symptoms Link.Psychologica Belgica · 2020Article
- Development and change in attachment: A multiwave assessment of attachment and its correlates across childhood and adolescence.Journal of personality and social psychology · 2020Article
- The Potential Role of Epigenetic Drugs in the Treatment of Anxiety Disorders.Neuropsychiatric disease and treatment · 2020Review
- Early Secure Attachment as a Protective Factor Against Later Cognitive Decline and Dementia.Frontiers in aging neuroscience · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
We examined the prediction that the interaction between Glucocorticoid Receptor Gene (NR3C1) methylation, stress, and experienced maternal support predicts anxious and avoidant attachment development. This was tested in a general population sample of 487 children and adolescents (44% boys, Mage = 11.84, SDage = 2.4). These children were followed over a period of 18 months. In line with the prediction, we found that NR3C1 methylation moderates the effect of maternal support during stress on anxious attachment development 18 months later. More stressed children who experienced less maternal support reported increased anxious attachment when their NR3C1 gene was highly methylated. This effect could not be explained by children's level of psychopathology. No effects were found for attachment avoidance. These data provide the first prospective evidence that epigenetic processes are involved in attachment development. (PsycINFO Database Record
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.