Evidence map›Paper›PMID 29058631›Full record

SynthesisBMC cancer2017

Exercise and cancer-related fatigue in adults: a systematic review of previous systematic reviews with meta-analyses.

George A Kelley, Kristi S Kelley

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05067777 (Massage for Prostate Cancer-Related Fatigue), which is not on this map. Cited by 30 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 11 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05067777 phase2terminatednot on this mapstarted 2022, after this paper: background citation

Massage for Prostate Cancer-Related Fatigue (mPROSTATE)

TypeinterventionalSponsorUniversity of UtahRan2022 to 2025Enrolled28ConditionsProstate CarcinomaArmsSwedish Massage Therapy (SMT), Light Touch (LT) Control, Waitlist Control (WLC)
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 11 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Effectiveness of exercise interventions in the management of cancer-related fatigue: a systematic review of systematic reviews.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Cancer-related fatigue in patients treated with mistletoe extracts: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
  6. Effectiveness of exercise training on cancer-related fatigue in colorectal cancer survivors: a systematic review and meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
  7. Do Patients with Prostate Cancer Benefit from Exercise Interventions? A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
    Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Trial
  13. Review
  14. Observational
  15. Review
  16. Article
  17. Review
  18. Article
  19. Returning to Sport: Female Athletes Living with and beyond Cancer.International journal of environmental research and public health · 2021
    Article
  20. Now we are 30: 10 more years of MASCC.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

George A KelleyMeta-Analytic Research Group, School of Public Health, Department of Biostatistics, Director, WVCTSI Clinical Research Design, Epidemiology, and Biostatistics (CRDEB) Program, PO Box 9190, Robert C. Byrd Health Sciences Center, Room 2350-A, Morgantown, West Virginia, 26506-9190, USA. gkelley@hsc.wvu.edu.
Kristi S KelleyMeta-Analytic Research Group, School of Public Health, Department of Biostatistics, PO Box 9190, Robert C. Byrd Health Sciences Center, Room 2350-B, Morgantown, West Virginia, 26506-9190, USA.
West Virginia University · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI JUDITH FEINBERG · 2012 to 2026
$81.0M
NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

backgroundConduct a systematic review of previous systematic reviews with meta-analysis to determine the effects of exercise (aerobic, strength or both) on cancer-related-fatigue (CRF) in adults with any type of cancer.

methodsSystematic reviews with meta-analyses of previous randomized controlled trials published through July of 2016 were included by searching six electronic databases and cross-referencing. Dual-selection and data abstraction were conducted. Methodological quality was assessed using the Assessment of Multiple Systematic Reviews (AMSTAR) instrument. Standardized mean differences (SMD) that were pooled using random-effects models were included as the effect size. In addition, 95% prediction intervals (PI), number needed-to-treat (NNT) and percentile improvements were calculated.

resultsSixteen studies representing 2 to 48 SMD effect sizes per analysis (mean ± SD, 7 ± 8, median = 5) and 37 to 3254 participants (mean ± SD, 633 ± 690, median = 400) were included. Length of training lasted from 3 to 52 weeks (mean ± SD, 14.6 ± 3.1, median = 14), frequency from 1 to 10 times per week (mean ± SD, 3.4 ± 0.8, median = 3), and duration from 10 to 120 min per session (mean ± SD, 44.3 ± 5.5, median = 45). Adjusted AMSTAR scores ranged from 44.4% to 80.0% (mean ± SD, 68.8% ± 12.0%, median = 72.5%). Overall, mean SMD improvements in CRF ranged from -1.05 to -0.01, with 22 of 55 meta-analytic results (52.7%) statistically significant (non-overlapping 95% CI). When PI were calculated for results with non-overlapping 95% CI, only 3 of 25 (12%) yielded non-overlapping 95% PI favoring reductions in CRF. Number needed-to-treat and percentile improvements ranged from 3 to 16 and 4.4 to 26.4, respectively.

conclusionsA lack of certainty exists regarding the benefits of exercise on CRF in adults. However, exercise does not appear to increase CRF in adults.

trial registrationPROSPERO Registration # CRD42016045405 .

Indexed as

ExerciseAdultAgedFatigueFemaleHumansMaleMiddle AgedModels, StatisticalNeoplasmsRandomized Controlled Trials as TopicCancerExerciseFatigueMeta-analysisSystematic review

Identifiers

PMID29058631
PMCPMC5651567
OpenAlexW2765975718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.