ArticleBMC physiology2017
Adiponectin is required for maintaining normal body temperature in a cold environment.
Article in BMC physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Effects of isomaltulose on insulin resistance and metabolites in patients with non‑alcoholic fatty liver disease: A metabolomic analysis.Molecular medicine reports · 2018Trial
- GHSR suppression in neurons protects against aging-associated metabolic and cognitive impairments.GeroScience · 2026Article
- Exercise and cold exposure as dual physiological stressors in MASLD: AMPK-mediated metabolic adaptation and interorgan crosstalk.Frontiers in physiology · 2026Review
- Cold climate and obesity in China: a cross-sectional ecological analysis.Frontiers in public health · 2025Article
- Metabolic resilience governs sex-specific pain recovery during hormonal aging: a multi-omics study of neuropathy in mice.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- MicroRNA-21 modulates brown adipose tissue adipogenesis and thermogenesis in a mouse model of polycystic ovary syndrome.Biology of sex differences · 2024Article
- Therapeutic potential of adiponectin in prediabetes: strategies, challenges, and future directions.Therapeutic advances in endocrinology and metabolism · 2024Review
- Molecular Mechanisms of Lipid-Based Metabolic Adaptation Strategies in Response to Cold.Cells · 2023Review
- Multi-omics signatures of the human early life exposome.Nature communications · 2022Article
- Adiponectin: friend or foe in obesity and inflammation.Medical review (2021) · 2022Review
- Article
- Leptin and adiponectin regulate the activity of nuclei involved in sleep-wake cycle in male rats.Frontiers in neuroscience · 2022Article
- Endothelial NOX5 Expression Modulates Thermogenesis and Lipolysis in Mice Fed with a High-Fat Diet and 3T3-L1 Adipocytes through an Interleukin-6 Dependent Mechanism.Antioxidants (Basel, Switzerland) · 2021Article
- Metabolic and inflammatory functions of cannabinoid receptor type 1 are differentially modulated by adiponectin.World journal of diabetes · 2021Article
- Human Milk Drives the Intimate Interplay Between Gut Immunity and Adipose Tissue for Healthy Growth.Frontiers in immunology · 2021Review
- Combined extracts of Moringa oleifera, Murraya koeingii leaves, and Curcuma longa rhizome increases energy expenditure and controls obesity in high-fat diet-fed rats.Lipids in health and disease · 2020Article
- Crosstalk Between Mast Cells and Adipocytes in Physiologic and Pathologic Conditions.Clinical reviews in allergy & immunology · 2020Review
- Weight Loss and Concomitant Adipose Autophagy in Methionine-Restricted Obese Mice is Not Dependent on Adiponectin or FGF21.Obesity (Silver Spring, Md.) · 2020Article
- Fibroblast Growth Factor-21, Leptin, and Adiponectin Responses to Acute Cold-Induced Brown Adipose Tissue Activation.The Journal of clinical endocrinology and metabolism · 2020Article
- Adiponectin homolog osmotin, a potential anti-obesity compound, suppresses abdominal fat accumulation in C57BL/6 mice on high-fat diet and in 3T3-L1 adipocytes.International journal of obesity (2005) · 2019Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundThermogenic impairment promotes obesity and insulin resistance. Adiponectin is an important regulator of energy homeostasis. While many beneficial metabolic effects of adiponectin resemble that of activated thermogenesis, the role of adiponectin in thermogenesis is not clear. In this study, we investigated the role of adiponectin in thermogenesis using adiponectin-null mice (Adipoq
methodsBody composition was measured using EchoMRI. Metabolic parameters were determined by indirect calorimetry. Insulin sensitivity was evaluated by glucose- and insulin- tolerance tests. Core body temperature was measured by a TH-8 temperature monitoring system. Gene expression was assessed by real-time PCR and protein levels were analyzed by Western blotting and immunohistochemistry. The mitochondrial density of brown adipose tissue was quantified by calculating the ratio of mtDNA:total nuclear DNA.
resultsUnder normal housing temperature of 24 °C and ad libitum feeding condition, the body weight, body composition, and metabolic profile of Adipoq
conclusionsOur findings demonstrate that adiponectin is an essential regulator of thermogenesis, and adiponectin is required for maintaining body temperature under cold exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.