ArticleHuman brain mapping2018
Identifying disease foci from static and dynamic effective connectivity networks: Illustration in soldiers with trauma.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 58 citations in OpenAlex.
- Neuroimaging correlates and predictors of response to repeated-dose intravenous ketamine in PTSD: preliminary evidence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- Establishing the link between post-concussive symptoms and brain network dysfunction: A systematic scoping review of neuroimaging evidence.NeuroImage. Clinical · 2026Article
- Mathematical and Dynamic Modeling of the Anatomical Localization of the Insula in the Brain.Neuroinformatics · 2025Review
- Topology Assisted Clustering of Temporal fMRI Brain Networks With Use-Case in Mitigating Non-Neural Multi-Site Variability.IEEE access : practical innovations, open solutions · 2025Article
- The neurophysiological consequences of racism-related stressors in Black Americans.Neuroscience and biobehavioral reviews · 2024Review
- The application of machine learning techniques in posttraumatic stress disorder: a systematic review and meta-analysis.NPJ digital medicine · 2024Review
- Multi-modal MRI of hippocampal morphometry and connectivity after pediatric severe TBI.Brain imaging and behavior · 2024Article
- ENIGMA's simple seven: Recommendations to enhance the reproducibility of resting-state fMRI in traumatic brain injury.NeuroImage. Clinical · 2024Review
- The confound of hemodynamic response function variability in human resting-state functional MRI studies.Frontiers in neuroscience · 2023Article
- Stress-Induced Changes in Effective Connectivity During Regulation of the Emotional Response to Threat.Brain connectivity · 2022Article
- Hippocampal Resting-State Functional Connectivity Forecasts Individual Posttraumatic Stress Disorder Symptoms: A Data-Driven Approach.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Dynamic Effective Connectivity Patterns During Rapid Face Stimuli Presentation in Body Dysmorphic Disorder.Frontiers in neuroscience · 2022Article
- Connective profiles and antagonism between dynamic and static connectivity underlying generalized epilepsy.Brain structure & function · 2021Article
- FMRI hemodynamic response function (HRF) as a novel marker of brain function: applications for understanding obsessive-compulsive disorder pathology and treatment response.Brain imaging and behavior · 2021Article
- Multipurpose Spatiomotor Capture System for Haptic and Visual Training and Testing in the Blind and Sighted.IS&T International Symposium on Electronic Imaging · 2021Article
- Density-based clustering of static and dynamic functional MRI connectivity features obtained from subjects with cognitive impairment.Brain informatics · 2020Article
- Saliva microRNA Biomarkers of Cumulative Concussion.International journal of molecular sciences · 2020Article
- Toward Robust Anxiety Biomarkers: A Machine Learning Approach in a Large-Scale Sample.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- MALINI (Machine Learning in NeuroImaging): A MATLAB toolbox for aiding clinical diagnostics using resting-state fMRI data.Data in brief · 2020Article
- DisConICA: a Software Package for Assessing Reproducibility of Brain Networks and their Discriminability across Disorders.Neuroinformatics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain connectivity studies report group differences in pairwise connection strengths. While informative, such results are difficult to interpret since our understanding of the brain relies on region-based properties, rather than on connection information. Given that large disruptions in the brain are often caused by a few pivotal sources, we propose a novel framework to identify the sources of functional disruption from effective connectivity networks. Our approach integrates static and time-varying effective connectivity modeling in a probabilistic framework, to identify aberrant foci and the corresponding aberrant connectomics network. Using resting-state fMRI, we illustrate the utility of this novel approach in U.S. Army soldiers (N = 87) with posttraumatic stress disorder (PTSD), mild traumatic brain injury (mTBI) and combat controls. Additionally, we employed machine-learning classification to identify those significant connectivity features that possessed high predictive ability. We identified three disrupted foci (middle frontal gyrus [MFG], insula, hippocampus), and an aberrant prefrontal-subcortical-parietal network of information flow. We found the MFG to be the pivotal focus of network disruption, with aberrant strength and temporal-variability of effective connectivity to the insula, amygdala and hippocampus. These connectivities also possessed high predictive ability (giving a classification accuracy of 81%); and they exhibited significant associations with symptom severity and neurocognitive functioning. In summary, dysregulation originating in the MFG caused elevated and temporally less-variable connectivity in subcortical regions, followed by a similar effect on parietal memory-related regions. This mechanism likely contributes to the reduced control over traumatic memories leading to re-experiencing, hyperarousal and flashbacks observed in soldiers with PTSD and mTBI. Hum Brain Mapp 39:264-287, 2018. © 2017 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.