ArticleHuman brain mapping2018
Radiation-induced brain structural and functional abnormalities in presymptomatic phase and outcome prediction.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Diffusion tensor imaging indices as biomarkers for cognitive changes following paediatric radiotherapy: a systematic review and meta-analysis.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2022Pooled it
- The impact of radiation-induced temporal lobe injury on cognition and structure across the whole brain in nasopharyngeal carcinoma patients.IBRO neuroscience reports · 2026Article
- Composite quantitative structural magnetic resonance imaging-based risk scoring model for predicting radiation-induced temporal lobe necrosis in nasopharyngeal carcinoma: a novel risk stratification model.Radiation oncology (London, England) · 2025Article
- Radiation-induced white matter dysfunction in patients with nasopharyngeal carcinoma.Frontiers in neuroscience · 2025Article
- Evaluation of the potential of diffusion tensor imaging biomarkers in prediction of white matter changes after brain radiation therapy: A systematic review.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025Review
- Radiation-induced aberrant structural covariance networks in patients with nasopharyngeal carcinoma: a source-based morphometry study.Quantitative imaging in medicine and surgery · 2024Article
- A high-density multi-electrode platform examining the effects of radiation on in vitro cortical networks.Scientific reports · 2024Article
- A bibliometric analysis of radiation-induced brain injury: a research of the literature from 1998 to 2023.Discover oncology · 2024Article
- Remote assessment of cognition and quality of life following radiotherapy for nasopharyngeal carcinoma: deep-learning-based predictive models and MRI correlates.Journal of cancer survivorship : research and practice · 2024Article
- Brain Plasticity Profiling as a Key Support to Therapeutic Decision-Making in Low-Grade Glioma Oncological Strategies.Cancers · 2023Review
- Brain diffusion MRI biomarkers after oncology treatments.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2023Review
- Radiation-induced glymphatic dysfunction in patients with nasopharyngeal carcinoma: a study using diffusion tensor image analysis along the perivascular space.Frontiers in neuroscience · 2023Article
- MRI-based radiomics models for the early prediction of radiation-induced temporal lobe injury in nasopharyngeal carcinoma.Frontiers in neurology · 2023Article
- A Personalized Longitudinal Strategy in Low-Grade Glioma Patients: Predicting Oncological and Neural Interindividual Variability and Its Changes over Years to Think One Step Ahead.Journal of personalized medicine · 2022Review
- Radiation Oncology: Future Vision for Quality Assurance and Data Management in Clinical Trials and Translational Science.Frontiers in oncology · 2022Review
- Research progress on mechanism and imaging of temporal lobe injury induced by radiotherapy for head and neck cancer.European radiology · 2022Review
- Interaction of chemotherapy and radiotherapy in altering the shape of subcortical structures in patients with nasopharyngeal carcinoma.Frontiers in oncology · 2022Article
- White Matter Tracts and Diffuse Lower-Grade Gliomas: The Pivotal Role of Myelin Plasticity in the Tumor Pathogenesis, Infiltration Patterns, Functional Consequences and Therapeutic Management.Frontiers in oncology · 2022Review
- Structure-Function Decoupling: A Novel Perspective for Understanding the Radiation-Induced Brain Injury in Patients With Nasopharyngeal Carcinoma.Frontiers in neuroscience · 2022Article
- Alterations in white matter fiber density associated with structural MRI and metabolic PET lesions following multimodal therapy in glioma patients.Frontiers in oncology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Radiation therapy, a major method of treatment for brain cancer, may cause severe brain injuries after many years. We used a rare and unique cohort of nasopharyngeal carcinoma patients with normal-appearing brains to study possible early irradiation injury in its presymptomatic phase before severe, irreversible necrosis happens. The aim is to detect any structural or functional imaging biomarker that is sensitive to early irradiation injury, and to understand the recovery and progression of irradiation injury that can shed light on outcome prediction for early clinical intervention. We found an acute increase in local brain activity that is followed by extensive reductions in such activity in the temporal lobe and significant loss of functional connectivity in a distributed, large-scale, high-level cognitive function-related brain network. Intriguingly, these radiosensitive functional alterations were found to be fully or partially recoverable. In contrast, progressive late disruptions to the integrity of the related far-end white matter structure began to be significant after one year. Importantly, early increased local brain functional activity was predictive of severe later temporal lobe necrosis. Based on these findings, we proposed a dynamic, multifactorial model for radiation injury and another preventive model for timely clinical intervention. Hum Brain Mapp 39:407-427, 2018. © 2017 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.