ArticleAnnals of surgical oncology2018
Vitamin Status and the Development of Postoperative Cognitive Decline in Elderly Surgical Oncologic Patients.
Article in Annals of surgical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Pooled it
- Co-occurrence of CT-based radiological sarcopenia and frailty are related to impaired survival in surgical oncology.The British journal of radiology · 2025Article
- Middle aged CAMKII-Cre:CbsExperimental animals · 2024Article
- Association between anaesthesia-related factors and postoperative neurocognitive disorder: a post-hoc analysis.BMC anesthesiology · 2023Observational
- Article
- Timed up and go test and long-term survival in older adults after oncologic surgery.BMC geriatrics · 2022Article
- Review
- Age-related differences in self-report and objective measures of cognitive function in older patients prior to chemotherapy.Nursing open · 2022Review
- Oxidative Stress Predicts Post-Surgery Complications in Gastrointestinal Cancer Patients.Annals of surgical oncology · 2022Article
- The association between the inflammatory response following surgery and post-operative delirium in older oncological patients: a prospective cohort study.Age and ageing · 2022Article
- Preoperative homocysteine modifies the association between postoperative C-reactive protein and postoperative delirium.Frontiers in aging neuroscience · 2022Article
- Association between preoperative serum homocysteine and delayed neurocognitive recovery after non-cardiac surgery in elderly patients: a prospective observational study.Perioperative medicine (London, England) · 2021Article
- Circulating B-vitamin biomarkers and B-vitamin supplement use in relation to quality of life in patients with colorectal cancer: results from the FOCUS consortium.The American journal of clinical nutrition · 2021Article
- Article
- Patients with head and neck cancer: Are they frailer than patients with other solid malignancies?European journal of cancer care · 2020Observational
- Hyperhomocysteinemia is key for increased susceptibility to PND in aged mice.Annals of clinical and translational neurology · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to evaluate the influence that serum levels of vitamin B12, folate, and homocysteine have on the development of short-term postoperative cognitive decline in the elderly surgical oncology patient.
methodsThis study was part of a prospective cohort study focused on postoperative cognitive outcomes for patients 65 years of age or older undergoing surgery for a solid malignancy. Postoperative cognitive decline was defined as the change in the combined results of the Ruff Figural Fluency Test and the Trail-Making Test Parts A and B. Patients with the highest change in scores 2 weeks postoperatively compared with baseline were considered to be patients with cognitive decline. Patients with the lowest change were considered to be patients without cognitive decline. To analyze the effect of vitamin levels on the changes in postoperative cognitive scores, uni- and multivariate logistic regression analysis were performed.
resultsThe study enrolled 61 patients with and 59 patients without postoperative cognitive decline. Hyperhomocysteinemia was present in 14.2% of the patients. Patients with postoperative cognitive decline more often had hyperhomocysteinemia (27.9 vs 10.2%). Hyperhomocysteinemia was associated with a higher chance for the development of postoperative cognitive decline (odds ratio
conclusionPreoperative hyperhomocysteinemia is associated with the development of postoperative cognitive decline. The presence of preoperative hyperhomocysteinemia could be an indicator for an increased risk of postoperative cognitive decline developing in the elderly.
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