Evidence map›Paper›PMID 29058051›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2018

Danshen (Salvia miltiorrhiza) protects ovariectomized rats fed with high-saturated fat-sucrose diet from bone loss.

X L Dong, W X Yu, C M Li, S He, L P Zhou, C W Poon, M S Wong

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In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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  3. Review
  4. Expanding the therapeutic potential ofFrontiers in pharmacology · 2023
    Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

X L DongState Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, People's Republic of China.
W X YuState Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, People's Republic of China.
C M LiState Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, People's Republic of China.
S HeDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Y806, Hung Hom, Kowloon, Hong Kong, People's Republic of China.
L P ZhouDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Y806, Hung Hom, Kowloon, Hong Kong, People's Republic of China.
C W PoonDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Y806, Hung Hom, Kowloon, Hong Kong, People's Republic of China.
M S WongState Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, People's Republic of China. man-sau.wong@polyu.edu.hk.

Funding

National Natural Science Foundation of China 81528024National Natural Science Foundation of China 81601110Shenzhen Basic Research Program JCY20150630115257900Shenzhen Basic Research Program JCYJ20140819153305696
6 · The paper itself

Abstract

Dietary patterns may interfere with the efficacy of herbal intervention. Our results demonstrated the protective effects of Salvia miltiorrhiza aqueous extract (SMA) on bone metabolism were influenced by levels of dietary fat and sucrose in ovariectomized (OVX) rats through its actions on attenuating lipid deposition and oxidative stress in rats.

introductionSalvia miltiorrhiza (SM), also known as Danshen, has been tested as an osteoporosis treatment in a series of small, short human trials that generally report improvements in bone property. However, dietary patterns may interfere with the effects of herbal intervention. We hypothesized that dietary fat and sucrose levels could influence the effects of SM supplementation on bone in estrogen-deficient animals.

methodsSix-month-old Sprague-Dawley sham or OVX rats were fed either a low-saturated fat-sucrose (LFS, a diet that was similar in composition to normal rat chow) or a high-fat-sucrose (HFS) diet and OVX rats were treated (8 rats/group) with SM aqueous extract (SMA, 600 mg/kg/day), 17β-estradiol (1 mg/kg/day), or vehicle for 12 weeks.

resultsSMA significantly improved bone properties as revealed by the increase in trabecular bone mineral density and decrease in trabecular separation at proximal metaphysis of the tibia (PT) in HFS-fed OVX rats, but not in LFS-fed OVX rats. SMA greatly reduced lipid deposition and malondialdehyde levels, improved the activities of superoxide dismutase, catalase, and glutathione peroxidase in the livers of HFS-fed OVX rats. SMA could directly improve the proliferation and differentiation in vitro in an H

conclusionsThe protective effects of SMA on bone metabolism were influenced by dietary fat and sucrose levels in OVX rats. The ability of SMA to reduce bone loss in HFS-fed OVX rats was associated with the attenuation of lipid deposition and oxidative stress levels.

Indexed as

Diet, High-FatAnimal Nutritional Physiological PhenomenaAnimalsBody WeightDietary FatsDietary SucroseDrug Evaluation, PreclinicalDrugs, Chinese HerbalFatty AcidsFemaleHumansLipid MetabolismLiverOrgan SizeOsteoporosis, PostmenopausalOvariectomydan-shen root extractDietary FatsDietary SucroseDrugs, Chinese HerbalFatty AcidsBone lossEstrogen deficiencyHigh-saturated fat-sucrose dietOxidative stressSalvia miltiorrhiza aqueous extract

Identifiers

PMID29058051

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.