ArticlePediatric radiology2018
Agreement between manual relaxometry and semi-automated scanner-based multi-echo Dixon technique for measuring liver T2* in a pediatric and young adult population.
Article in Pediatric radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- MR and Ultrasound for Liver Fat Assessment in Children: Techniques and Supporting Evidence.Journal of magnetic resonance imaging : JMRI · 2025Review
- State-of-the-Art Quantification of Liver Iron With MRI-Vendor Implementation and Available Tools.Journal of magnetic resonance imaging : JMRI · 2025Review
- Clinical benefits of MRI-guided freehand biopsy of small focal liver lesions in comparison to CT guidance.European radiology · 2024Article
- Intra-examination agreement between multi-echo gradient echo and confounder-corrected chemical shift-encoded MR sequences for R2* estimation as a biomarker of liver iron content in patients with a wide range of T2*/R2* and proton density fat fraction values.Abdominal radiology (New York) · 2023Article
- Rate of Change of Liver Iron Content by MR Imaging Methods: A Comparison Study.Tomography (Ann Arbor, Mich.) · 2022Article
- Comparison of Inline R2* MRI versus FerriScan for liver iron quantification in patients on chelation therapy for iron overload: preliminary results.European radiology · 2021Article
- Imaging Modalities in Pediatric NAFLD.Clinical liver disease · 2021Review
- MR imaging assessment and quantification of liver iron.Abdominal radiology (New York) · 2020Review
- Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCommercially available 3D multi-echo Dixon (mDixon) sequences provide parametric maps of liver T2*, obviating manual curve fitting that is often required with conventional gradient recalled echo (GRE)-based multi-echo relaxometry, potentially simplifying clinical work flow.
objectiveThe purpose of our study was to compare T2* values generated by a 3D mDixon sequence to values generated by GRE-based T2* relaxometry with manual curve fitting in a pediatric and young adult population. MATERIALS AND
methodsWe reviewed clinical MRI exams performed at 1.5T for liver iron content estimation between February 2015 and June 2016 that included both mDixon and multi-echo GRE pulse sequences. We obtained mean T2* measurements based on each sequence by drawing regions of interest on each of four axial slices through the mid-liver. We compared mDixon-based and GRE-based T2* measurements using paired t-tests and assessed agreement using single-measure intra-class correlation coefficients and Bland-Altman difference plots.
resultsOne hundred nine patients met inclusion criteria (site 1=82; site 2=27). Mean age was 12.4±5.8 years, and 42 subjects (39%) were female. There was no statistically significant difference in mean T2* values for the two sequences (pooled means: 11.7±11.0 [GRE] vs. 11.7±10.9 ms [mDixon]; P=0.93). There was excellent absolute agreement between sequences (intraclass correlation coefficient [ICC]=0.98 for patients at both sites, confidence interval [CI]: 0.97-0.98 with mean bias of 0.0 ms [-4.2 ms to +4.2 ms]).
conclusion3D mDixon is accurate for measuring liver T2* and can likely replace 2D GRE-based relaxometry.
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