Evidence map›Paper›PMID 29058035›Full record

ArticleCancer immunology, immunotherapy : CII2018

NY-ESO-1- and survivin-specific T-cell responses in the peripheral blood from patients with glioma.

Zhenjiang Liu, Thomas Poiret, Oscar Persson, Qingda Meng, Lalit Rane, Jiri Bartek, Julia Karbach, Hans-Michael Altmannsberger, Christopher Illies, Xiaohua Luo and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Zhenjiang LiuTherapeutic Immunology, F79, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Hälsovägen, Huddinge, 14186, Stockholm, Sweden.
Thomas PoiretTherapeutic Immunology, F79, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Hälsovägen, Huddinge, 14186, Stockholm, Sweden.
Oscar PerssonDepartment of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.
Qingda MengTherapeutic Immunology, F79, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Hälsovägen, Huddinge, 14186, Stockholm, Sweden.
Lalit RaneTherapeutic Immunology, F79, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Hälsovägen, Huddinge, 14186, Stockholm, Sweden.
Jiri BartekDepartment of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.
Julia KarbachDepartment of Oncology and Hematology, Krankenhaus Nordwest, Frankfurt/Main, Germany.
Hans-Michael AltmannsbergerInstitute of Pathology, Krankenhaus Nordwest, Frankfurt/Main, Germany.
Christopher IlliesDepartment of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.
Xiaohua LuoTherapeutic Immunology, F79, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Hälsovägen, Huddinge, 14186, Stockholm, Sweden.
Inti Harvey-PeredoDepartment of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.
Elke JägerDepartment of Oncology and Hematology, Krankenhaus Nordwest, Frankfurt/Main, Germany.
Ernest DodooDepartment of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.
Markus MaeurerTherapeutic Immunology, F79, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Hälsovägen, Huddinge, 14186, Stockholm, Sweden. markus.maeurer@gmail.com.
Karolinska University Hospital · SEKrankenhaus Nordwest · DEKarolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prognosis for patients with glioblastoma is grim. Ex vivo expanded tumor-associated antigen (TAA)-reactive T-cells from patients with glioma may represent a viable source for anticancer-directed cellular therapies. Immunohistochemistry was used to test the survivin (n = 40 samples) and NY-ESO-1 (n = 38 samples) protein expression in tumor specimens. T-cells from peripheral blood were stimulated with TAAs (synthetic peptides) in IL-2 and IL-7, or using a combination of IL-2, IL-15 and IL-21. CD4

Indexed as

AdultAgedAntigens, NeoplasmBrain NeoplasmsCell Line, TumorEnzyme-Linked Immunosorbent AssayEpitopes, T-LymphocyteGlioblastomaHumansInterferon-gammaMembrane ProteinsMiddle AgedPeptidesPrognosisSurvivinT-LymphocytesAntigens, NeoplasmBIRC5 protein, humanCTAG1B protein, humanEpitopes, T-LymphocyteInterferon-gammaMembrane ProteinsPeptidesSurvivinCellular therapyGliomaImmunotherapyNY-ESO-1SurvivinT-cells

Identifiers

PMID29058035
PMCPMC5799356
OpenAlexW2765753210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.