ArticleSpinal cord2018
Spinal cord injury and Alzheimer's disease risk: a population-based, retrospective cohort study.
Article in Spinal cord, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Acute effects of neuromuscular electrical stimulation on lactate, IGF-1 and cognition in chronic spinal cord injury: A pilot randomized cross-over study.The journal of spinal cord medicine · 2026Trial
- Article
- Repeated mild spinal cord contusions exacerbate tauopathy development in PS19 mice.Acta neuropathologica communications · 2026Article
- Comparative analyses of regional and temporal transcriptomics of early human and mouse central nervous systems.iScience · 2026Article
- Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer's disease via dysregulation of CCK neurons.Nature neuroscience · 2026Article
- Barriers and Facilitators in Access to Care Among Adults With Traumatic Spinal Cord Injuries: A Qualitative Study Comparing VA and Commercial Insurance.Health services insights · 2026Article
- Identifying Likely Incidents of Traumatic Spinal Cord Injury and Elevated Risk of Alzheimer's Disease and Related Dementia: Health Care Cost Institute Data.Topics in spinal cord injury rehabilitation · 2025Article
- Incident traumatic spinal cord injury and risk of Alzheimer's disease and related dementia: longitudinal case and control cohort study.Spinal cord · 2024Article
- Old age alters inflammation and autophagy signaling in the brain, leading to exacerbated neurological outcomes after spinal cord injury in male mice.Brain, behavior, and immunity · 2024Article
- Neuromuscular electrical stimulation to combat cognitive aging in people with spinal cord injury: protocol for a single case experimental design study.BMC neurology · 2024Article
- The impact of sulfatide loss on the progress of Alzheimer's disease.Clinical and translational discovery · 2023Article
- Cognitive and physical impairment in spinal cord injury: A scoping review and call for new understanding.The journal of spinal cord medicine · 2023Article
- Acute Transcriptomic and Epigenetic Alterations at T12 After Rat T10 Spinal Cord Contusive Injury.Molecular neurobiology · 2023Article
- Anti-Inflammatory CDGSH Iron-Sulfur Domain 2: A Biomarker of Central Nervous System Insult in Cellular, Animal Models and Patients.Biomedicines · 2022Article
- Use of Zebrafish Genetic Models to Study Etiology of the Amyloid-Beta and Neurofibrillary Tangle Pathways in Alzheimer's Disease.Current neuropharmacology · 2022Review
- Traumatic Spinal Cord Injury and Risk of Early and Late Onset Alzheimer's Disease and Related Dementia: Large Longitudinal Study.Archives of physical medicine and rehabilitation · 2021Article
- The Potential Role of Inflammation in Modulating Endogenous Hippocampal Neurogenesis After Spinal Cord Injury.Frontiers in neuroscience · 2021Review
- Ultrarapid Inflammation of the Olfactory Bulb After Spinal Cord Injury: Protective Effects of the Granulocyte Colony-Stimulating Factor on Early Neurodegeneration in the Brain.Frontiers in aging neuroscience · 2021Article
- Lentivirus-mediated downregulation of α-synuclein reduces neuroinflammation and promotes functional recovery in rats with spinal cord injury.Journal of neuroinflammation · 2019Article
- An Overview of Experimental and Clinical Spinal Cord Findings in Alzheimer's Disease.Brain sciences · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designPropensity score-matched, retrospective cohort study.
objectivesTo determine the risk of developing Alzheimer's disease (AD) in patients with spinal cord injury (SCI).
settingThe present study used Taiwan's National Health Insurance Research Database.
methodsA total of 9257 patients who had ⩾2 ambulatory visits with a diagnosis of SCI in 2001 were included in the SCI group. The non-SCI group consisted of 37,028 propensity score-matched patients without a diagnosis of SCI. The cumulative incidence of AD was estimated for each of the two patient groups using the Kaplan-Meier method. Stratified Cox proportional hazard regression was then employed to assess the influence of SCI on the risk of AD.
resultsDuring the follow-up period, 25 subjects in the SCI group and 57 in the non-SCI group developed AD. The cumulative incidence of AD in the SCI group was higher than in the non-SCI group (P = 0.0168); and the hazard ratio of AD for the SCI group, as compared to the non-SCI group, was 1.71 (95% CI 1.06-2.76, P = 0.0273).
conclusionsThis study suggests that patients with SCI have an increased risk of developing AD.
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Registered trials
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