Evidence map›Paper›PMID 29057981›Full record

ArticleScientific reports2017

A New Generation of Arachidonic Acid Analogues as Potential Neurological Agent Targeting Cytosolic Phospholipase A

Cheng Yang Ng, Srinivasaraghavan Kannan, Yong Jun Chen, Francis Chee Kuan Tan, Wee Yong Ong, Mei Lin Go, Chandra S Verma, Chian-Ming Low, Yulin Lam

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Phospholipase A2 downregulates inhibitory transmission in the amygdala and impairs fear extinction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Review
  4. A perspective: PLA2G4A as drug target for vascular inflammation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. 1,4-Disubstituted 1International journal of molecular sciences · 2020
    Article
  11. Article
  12. Small-molecule inhibitors as potential therapeutics and as tools to understand the role of phospholipases ABiochimica et biophysica acta. Molecular and cell biology of lipids · 2019
    Review
  13. Lipid-metabolizing serine hydrolases in the mammalian central nervous system: endocannabinoids and beyond.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2019
    Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Cheng Yang NgDepartment of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore.
Srinivasaraghavan KannanBioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Matrix, Singapore, 138671, Singapore.
Yong Jun ChenDepartment of Pharmacy, National University of Singapore, 21 Lower Kent Ridge Road, Singapore, 119077, Singapore.
Francis Chee Kuan TanDepartment of Anaesthesia, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore.ORCID 0000-0002-5272-9990
Wee Yong OngDepartment of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore.
Mei Lin GoDepartment of Pharmacy, National University of Singapore, 21 Lower Kent Ridge Road, Singapore, 119077, Singapore.
Chandra S VermaBioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Matrix, Singapore, 138671, Singapore. chandra@bii.a-star.edu.sg.
Chian-Ming LowDepartment of Anaesthesia, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore. phclowcm@nus.edu.sg.
Yulin LamDepartment of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore. chmlamyl@nus.edu.sg.
National University of Singapore · SGAgency for Science, Technology and Research · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytosolic phospholipase A

Indexed as

AnimalsArachidonic AcidsBlood-Brain BarrierCell LineCell SurvivalDrug Evaluation, PreclinicalHumansMiceMicrogliaMolecular Docking SimulationNitric OxidePhospholipase A2 InhibitorsPhospholipases A2Reactive Oxygen SpeciesArachidonic AcidsarachidonyltrifluoromethaneNitric OxidePhospholipase A2 InhibitorsPhospholipases A2Reactive Oxygen Species

Identifiers

PMID29057981
PMCPMC5651845
OpenAlexW2766861970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.