ArticleScientific reports2017
Immunosenescence patterns differ between populations but not between sexes in a long-lived mammal.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Macroimmunology: The drivers and consequences of spatial patterns in wildlife immune defence.The Journal of animal ecology · 2020Pooled it
- Asynchrony of ageing among traits in a wild bird population.Evolution letters · 2026Article
- Longevity through immunity: the unusual naked mole-rat immune system.GeroScience · 2026Review
- Effects of host sex, age and behaviour on co-infection patterns in a wild ungulate.Parasitology · 2025Article
- Effects of forest structure on the endoparasitism in roe deer Capreolus capreolus.Parasite (Paris, France) · 2025Article
- The Promise of a Pointillist Perspective for Comparative Immunology.Physiology (Bethesda, Md.) · 2024Review
- Reproduction results in parallel changes of oxidative stress and immunocompetence in a wild long-living mammal-edible dormouseBiology letters · 2024Article
- Approaches and methods to study wildlife cancer.The Journal of animal ecology · 2024Review
- Essential mineral elements in roe deer: Associations with parasites and immune phenotypes in two contrasting populations.Ecology and evolution · 2024Article
- Large-scale across species transcriptomic analysis identifies genetic selection signatures associated with longevity in mammals.The EMBO journal · 2023Article
- Temporal dynamics of antibody level against Lyme disease bacteria in roe deer: Tale of a sentinel?Ecology and evolution · 2023Article
- Female reproduction and viral infection in a long-lived mammal.The Journal of animal ecology · 2022Article
- Variations in immune parameters with age in a wild rodent population and links with survival.Ecology and evolution · 2022Article
- Respiratory Disease Risk of Zoo-Housed Bonobos Is Associated with Sex and Betweenness Centrality in the Proximity Network.Animals : an open access journal from MDPI · 2021Article
- Metabarcoding in two isolated populations of wild roe deer (Capreolus capreolus) reveals variation in gastrointestinal nematode community composition between regions and among age classes.Parasites & vectors · 2021Article
- Reproductive females and young mouflon (Parasitology · 2021Article
- Urinary neopterin of wild chimpanzees indicates that cell-mediated immune activity varies by age, sex, and female reproductive status.Scientific reports · 2021Article
- Demography, life-history trade-offs, and the gastrointestinal virome of wild chimpanzees.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Faecal parasites increase with age but not reproductive effort in wild female chimpanzees.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Pathogens Shape Sex Differences in Mammalian Aging.Trends in parasitology · 2020Review
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Authors and funding
11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In animals, physiological mechanisms underlying reproductive and actuarial senescence remain poorly understood. Immunosenescence, the decline in the ability to display an efficient immune response with increasing age, is likely to influence both reproductive and actuarial senescence through increased risk of disease. Evidence for such a link has been reported from laboratory animal models but has been poorly investigated in the wild, where variation in resource acquisitions usually drives life-history trade-offs. We investigated immunosenescence patterns over 7 years in both sexes of two contrasting roe deer populations (Capreolus capreolus). We first measured twelve immune markers to obtain a thorough identification of innate and adaptive components of immunity and assessed, from the same individuals, the age-dependent variation observed in parasitic infections. Although the level of innate traits was maintained at old age, the functional innate immune traits declined with increasing age in one of two populations. In both populations, the production of inflammatory markers increased with advancing age. Finally, the adaptive response declined in late adulthood. The increasing parasite burden with age we reported suggests the effective existence of immunosenescence. Age-specific patterns differed between populations but not between sexes, which indicate that habitat quality could shape age-dependent immune phenotype in the wild.
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