Evidence map›Paper›PMID 29057934›Full record

ArticleNature communications2017

PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis.

Cristiano Sacchetti, Yunpeng Bai, Stephanie M Stanford, Paola Di Benedetto, Paola Cipriani, Eugenio Santelli, Sonsoles Piera-Velazquez, Vladimir Chernitskiy, William B Kiosses, Arnold Ceponis and 6 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04752397 (The Influence of Extracorporeal Photopheresis on Skin Sclerosis - an Exploratory Clinical Study), which is not on this map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04752397 completednot on this mapstarted 2021, after this paper: background citation

The Influence of Extracorporeal Photopheresis on Skin Sclerosis - an Exploratory Clinical Study

TypeobservationalSponsorCharite University, Berlin, GermanyRan2021 to 2021Enrolled6ConditionsScleroderma, Systemic, Graft Vs Host Disease, Eosinophilic Fasciitis, Morphea
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 54 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. EphB2 Receptor Promotes Dermal Fibrosis in Systemic Sclerosis.Arthritis & rheumatology (Hoboken, N.J.) · 2024
    Article
  10. Article
  11. Targeting PRL phosphatases in hematological malignancies.Expert opinion on therapeutic targets · 2024
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 2 countries.

Cristiano SacchettiDivision of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA.
Yunpeng BaiDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 610 Purdue Mall, West Lafayette, IN, 47907, USA.
Stephanie M StanfordDivision of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA.
Paola Di BenedettoRheumatology Division, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Giovanni di Vincenzo, 16/B, 67100, L'Aquila, Italy.
Paola CiprianiRheumatology Division, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Giovanni di Vincenzo, 16/B, 67100, L'Aquila, Italy.
Eugenio SantelliDivision of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA.
Sonsoles Piera-VelazquezScleroderma Center and Jefferson Institute of Molecular Medicine, 9035 Golden Sunset Ln, Springfield, VA, 22153, USA.
Vladimir ChernitskiyDivision of Rheumatology, Department of Medicine, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143, USA.
William B KiossesCore Microscopy Facility, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA, 92037, USA.
Arnold CeponisDivision of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA.
Klaus H KaestnerDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Francesco BoinDivision of Rheumatology, Department of Medicine, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143, USA.
Sergio A JimenezScleroderma Center and Jefferson Institute of Molecular Medicine, 9035 Golden Sunset Ln, Springfield, VA, 22153, USA.
Roberto GiacomelliRheumatology Division, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Giovanni di Vincenzo, 16/B, 67100, L'Aquila, Italy.
Zhong-Yin ZhangDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 610 Purdue Mall, West Lafayette, IN, 47907, USA.
Nunzio BottiniDivision of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA. nbottini@ucsd.edu.
La Jolla Institute for Immunology · USUniversity of L'Aquila · ITJefferson Institute · USPurdue University West Lafayette · USUniversity of California, San Francisco · USScripps Research Institute · USUniversity of California, San Diego · USUniversity of Pennsylvania · US

Funding

Structure/Function of Protein Tyrosine PhosphatasesR01CA069202 · NCI · YESHIVA UNIVERSITY · PI Zhong-Yin Zhang · 1996 to 2026
$7.3M
Role of PTP4A1 in systemic sclerosisR21AR069822 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOTTINI, NUNZIO · 2016 to 2017
$375k
NCI NIH HHS R01 CA069202NIAMS NIH HHS R21 AR069822
6 · The paper itself

Abstract

Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of skin and internal organs. Protein tyrosine phosphatases have received little attention in the study of SSc or fibrosis. Here, we show that the tyrosine phosphatase PTP4A1 is highly expressed in fibroblasts from patients with SSc. PTP4A1 and its close homolog PTP4A2 are critical promoters of TGFβ signaling in primary dermal fibroblasts and of bleomycin-induced fibrosis in vivo. PTP4A1 promotes TGFβ signaling in human fibroblasts through enhancement of ERK activity, which stimulates SMAD3 expression and nuclear translocation. Upstream from ERK, we show that PTP4A1 directly interacts with SRC and inhibits SRC basal activation independently of its phosphatase activity. Unexpectedly, PTP4A2 minimally interacts with SRC and does not promote the SRC-ERK-SMAD3 pathway. Thus, in addition to defining PTP4A1 as a molecule of interest for TGFβ-dependent fibrosis, our study provides information regarding the functional specificity of different members of the PTP4A subclass of phosphatases.

Indexed as

MAP Kinase Signaling SystemAnimalsCell LineDermisExtracellular Signal-Regulated MAP KinasesFemaleFibroblastsHumansImmediate-Early ProteinsMice, Inbred C57BLMice, KnockoutProtein Tyrosine PhosphatasesProto-Oncogene Proteins pp60(c-src)Scleroderma, SystemicSmad3 ProteinTransforming Growth Factor betaExtracellular Signal-Regulated MAP KinasesImmediate-Early ProteinsProtein Tyrosine PhosphatasesProto-Oncogene Proteins pp60(c-src)Ptp4a1 protein, mousePtp4a2 protein, mouseSmad3 ProteinSMAD3 protein, humanTransforming Growth Factor beta

Identifiers

PMID29057934
PMCPMC5651906
OpenAlexW2766936863

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.