ArticleScientific reports2017
Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Objective Sleep Assessment in Systemic Mastocytosis: Polysomnographic Findings from a Single-Center Observational Study.Journal of clinical medicine · 2026Article
- Hydrogen as a Potential Modulator: Implications for Mast Cell-Sleep-Wake Rhythm-Melatonin Interactions in Sleep Disorders.Molecular neurobiology · 2026Review
- Insomnia-related rodent models in drug discovery.Acta pharmacologica Sinica · 2024Review
- The sex-dependent response to psychosocial stress and ischaemic heart disease.Frontiers in cardiovascular medicine · 2023Review
- Brain Mast Cells in Sleep and Behavioral Regulation.Current topics in behavioral neurosciences · 2022Article
- Histamine and Microglia.Current topics in behavioral neurosciences · 2022Review
- Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice.Scientific reports · 2021Article
- Histamine: neural circuits and new medications.Sleep · 2019Review
- Are Polyunsaturated Fatty Acids Implicated in Histaminergic Dysregulation in Bipolar Disorder?: AN HYPOTHESIS.Frontiers in physiology · 2018Review
- Mast Cell Activation in Brain Injury, Stress, and Post-traumatic Stress Disorder and Alzheimer's Disease Pathogenesis.Frontiers in neuroscience · 2017Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have developed a chronic mild stress (MS) mouse model by simply rearing mice on a wire net for 3 weeks and investigated the effects of MS on glucose homeostasis and sleep. MS mice showed impaired glucose tolerance and disturbed sleep. One-week treatment with a histamine H1 receptor antagonist (H1RA) ameliorated the glucose intolerance and improved sleep quality in MS mice. MS mice showed an increased number of mast cells in both adipose tissue and the brain. Inhibition of mast cell function ameliorated the impairment in both glucose tolerance and sleep. Together, these findings indicate that mast cells may represent an important pathophysiological mediator in sleep and energy homeostasis.
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Registered trials
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