Evidence map›Paper›PMID 29057829›Full record

ArticleNutrients2017

Association of Vitamin E Levels with Metabolic Syndrome, and MRI-Derived Body Fat Volumes and Liver Fat Content.

Sabina Waniek, Romina di Giuseppe, Sandra Plachta-Danielzik, Ilka Ratjen, Gunnar Jacobs, Manja Koch, Jan Borggrefe, Marcus Both, Hans-Peter Müller, Jan Kassubek and 5 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
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  14. The Effect ofAnimals : an open access journal from MDPI · 2023
    Article
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  19. Enjoy Carefully: The Multifaceted Role of Vitamin E in Neuro-Nutrition.International journal of molecular sciences · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Sabina WaniekInstitute of Epidemiology, Christian-Albrechts University of Kiel, 24105 Kiel, Germany. sabina.waniek@epi.uni-kiel.de.ORCID 0000-0003-4381-9676
Romina di GiuseppeInstitute of Epidemiology, Christian-Albrechts University of Kiel, 24105 Kiel, Germany. romina.digiuseppe@epi.uni-kiel.de.
Sandra Plachta-DanielzikInstitute of Epidemiology, Christian-Albrechts University of Kiel, 24105 Kiel, Germany. sandra.plachta-danielzik@epi.uni-kiel.de.
Ilka RatjenInstitute of Epidemiology, Christian-Albrechts University of Kiel, 24105 Kiel, Germany. ilka.ratjen@epi.uni-kiel.de.
Gunnar JacobsInstitute of Epidemiology, Christian-Albrechts University of Kiel, 24105 Kiel, Germany. jacobs@popgen.de.
Manja KochInstitute of Epidemiology, Christian-Albrechts University of Kiel, 24105 Kiel, Germany. mkoch@hsph.harvard.edu.
Jan BorggrefeInstitute of Diagnostic and Interventional Radiology, University Hospital Cologne, 50937 Cologne, Germany. jan.borggrefe@uk-koeln.de.ORCID 0000-0003-2908-7560
Marcus BothDepartment of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany. Marcus.both@uksh.de.
Hans-Peter MüllerDepartment of Neurology, University of Ulm, 89081 Ulm, Germany. hans-peter.mueller@uni-ulm.de.
Jan KassubekDepartment of Neurology, University of Ulm, 89081 Ulm, Germany. jan.kassubek@uni-ulm.de.
Ute NöthlingsDepartment of Nutrition and Food Science, University of Bonn, 53113 Bonn, Germany. noethlings@uni-bonn.de.
Tuba EsatbeyogluInstitute of Human Nutrition and Food Science, Christian-Albrechts University of Kiel, 24118 Kiel, Germany. tuba.esatbeyoglu@mri.bund.de.
Sabrina SchlesingerInstitute for Biometrics and Epidemiology, German Diabetes Center (DDZ) at Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany. sabrina.schlesinger@DDZ.uni-duesseldorf.de.
Gerald RimbachInstitute of Human Nutrition and Food Science, Christian-Albrechts University of Kiel, 24118 Kiel, Germany. rimbach@foodsci.uni-kiel.de.
Wolfgang LiebInstitute of Epidemiology, Christian-Albrechts University of Kiel, 24105 Kiel, Germany. wolfgang.lieb@epi.uni-kiel.de.
Christian-Albrechts-Universität zu Kiel · DEUniversität Ulm · DEDeutsches Diabetes-Zentrum e.V. · DEHarvard University · USUniversity Hospital Cologne · DEUniversity Hospital Schleswig-Holstein · DEUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to relate circulating α- and γ-tocopherol levels to a broad spectrum of adiposityrelated traits in a cross-sectional Northern German study. Anthropometric measures were obtained, and adipose tissue volumes and liver fat were quantified by magnetic resonance imaging in 641 individuals (mean age 61 years; 40.6% women). Concentrations of α- and γ-tocopherol were measured using high performance liquid chromatography. Multivariable-adjusted linear and logistic regression were used to assess associations of circulating α- and γ-tocopherol/cholesterol ratio levels with visceral (VAT) and subcutaneous adipose tissue (SAT), liver signal intensity (LSI), fatty liver disease (FLD), metabolic syndrome (MetS), and its individual components. The α- tocopherol/cholesterol ratio was positively associated with VAT (β scaled by interquartile range (IQR): 0.036; 95%Confidence Interval (CI): 0.0003; 0.071) and MetS (Odds Ratio (OR): 1.83; 95% CI: 1.21-2.76 for 3rd vs. 1st tertile), and the γ-tocopherol/cholesterol ratio was positively associated with VAT (β scaled by IQR: 0.066; 95% CI: 0.027; 0.104), SAT (β scaled by IQR: 0.048; 95% CI: 0.010; 0.087) and MetS (OR: 1.87; 95% CI: 1.23-2.84 for 3rd vs. 1st tertile). α- and γ-tocopherol levels were positively associated with high triglycerides and low high density lipoprotein cholesterol levels (all Ptrend < 0.05). No association of α- and γ-tocopherol/cholesterol ratio with LSI/FLD was observed. Circulating vitamin E levels displayed strong associations with VAT and MetS. These observations lay the ground for further investigation in longitudinal studies.

Indexed as

AdiposityMagnetic Resonance ImagingAgedalpha-TocopherolBiomarkersChromatography, High Pressure LiquidCross-Sectional StudiesFemalegamma-TocopherolGermanyHumansIntra-Abdominal FatLinear ModelsLiverLogistic ModelsMalealpha-TocopherolBiomarkersgamma-TocopherolVitamin Ebody fat volumesliver fat contentmetabolic syndromevitamin Eα- and γ-tocopherol

Identifiers

PMID29057829
PMCPMC5691759
OpenAlexW2766930466

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.