ArticleThe European journal of neuroscience2018
Diminished socially selective neural processing in 5-month-old infants at high familial risk of autism.
Article in The European journal of neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cortical Region Reporting Patterns in Neurodevelopmental Disorders: A Systematic Review of fNIRS Studies.Biosensors · 2026Pooled it
- The Value of Brain Imaging and Electrophysiological Testing for Early Screening of Autism Spectrum Disorder: A Systematic Review.Frontiers in neuroscience · 2021Pooled it
- The Cost of Social Integration: Distinct Neural Inefficiency in Autistic Children Underlies Symptom Severity.Autism research : official journal of the International Society for Autism Research · 2026Article
- Face perception and impact of face masks at 6 months post-term age in preterm and term infants (The BabyFace Study).Scientific reports · 2026Article
- Functional specialisation across the first five years of life: A longitudinal characterisation of social perception with fNIRS.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Autism Spectrum Disorder in Children: Early Signs and Therapeutic Interventions.Children (Basel, Switzerland) · 2024Review
- Prefrontal Cortex Responses to Social Video Stimuli in Young Children with and without Autism Spectrum Disorder.Brain sciences · 2024Article
- Heterogeneity and convergence across seven neuroimaging modalities: a review of the autism spectrum disorder literature.Frontiers in psychiatry · 2024Review
- A Developmental Social Neuroscience Perspective on Infant Autism Interventions.Annual review of developmental psychology · 2023Article
- Using functional near-infrared spectroscopy to study the early developing brain: future directions and new challenges.Neurophotonics · 2023Article
- Prediction of autism in infants: progress and challenges.The Lancet. Neurology · 2023Review
- Task-based functional neuroimaging in infants: a systematic review.Frontiers in neuroscience · 2023Review
- Why do children with autism spectrum disorder have abnormal visual perception?Frontiers in psychiatry · 2023Article
- Modulation of EEG theta by naturalistic social content is not altered in infants with family history of autism.Scientific reports · 2022Article
- Neuroimaging Techniques as Descriptive and Diagnostic Tools for Infants at Risk for Autism Spectrum Disorder: A Systematic Review.Brain sciences · 2022Review
- The amplitude of fNIRS hemodynamic response in the visual cortex unmasks autistic traits in typically developing children.Translational psychiatry · 2022Article
- Looking for "fNIRS Signature" in Autism Spectrum: A Systematic Review Starting From Preschoolers.Frontiers in neuroscience · 2022Review
- Clinical Applications of Functional Near-Infrared Spectroscopy in Children and Adolescents with Psychiatric Disorders.Soa--ch'ongsonyon chongsin uihak = Journal of child & adolescent psychiatry · 2021Review
- Clinical and Translational Implications of an Emerging Developmental Substructure for Autism.Annual review of clinical psychology · 2021Article
- Regional Haemodynamic and Metabolic Coupling in Infants.Frontiers in human neuroscience · 2021Article
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Authors and funding
7 authors.
Funding
Abstract
The social and communicative difficulties that characterize autism spectrum disorder (ASD) are considered the most striking feature of the disorder. Research has reported that individuals with ASD show abnormalities in the brain regions associated with the processing of social information. Importantly, a recent study using functional near-infrared spectroscopy (fNIRS) found the first evidence of atypicalities in the neural processing of social information in 4- to 6-month-old infants at high familial risk of ASD. These findings provide an important step in the search for early markers of ASD and highlight the potential for neuroimaging techniques to detect atypical patterns of neural activity prior to the manifestation of most behavioural symptoms. This study aimed to extend the findings of reduced neural sensitivity to social stimuli in an independent cohort. Twenty-nine 5-month-old infants (13 low-risk infants, 16 high-risk infants) were presented with social and non-social visual stimuli, similar to the previous experiment. Importantly, a non-social dynamic motion control condition was introduced allowing the comparison between social dynamic and non-social, static, as well as dynamic stimuli. We found that while low-risk infants showed activation to social stimuli in the right posterior temporal cortex, this activation was reduced in infants at high risk of ASD. Although the current sample size was relatively small, our results replicate and extend previous work and provide evidence for a social processing difference in infants at risk of autism. Future research will determine whether these differences relate to an eventual ASD diagnosis or may rather reflect the broader autism phenotype.
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