ArticleInternational journal of paediatric dentistry2018
Exploring the genomic basis of early childhood caries: a pilot study.
Article in International journal of paediatric dentistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Pooled it
- Chicken eggshell paste versus CPP-ACP for enamel remineralization: a pilot in vitro study using micro-computed tomography.The Saudi dental journal · 2026Article
- Addressing Research Gaps in Early Childhood Caries: A Comprehensive Review.Dentistry journal · 2026Review
- Subtypes of early childhood caries predict future caries experience.Community dentistry and oral epidemiology · 2023Article
- Observational
- Potential risk factors and genetic variants associated with dental caries incidence in Appalachia using genome-wide survival analysis.International journal of molecular epidemiology and genetics · 2023Article
- Children's oral health-related behaviours and early childhood caries: A latent class analysis.Community dentistry and oral epidemiology · 2022Article
- Multi-marker genetic association and interaction tests with interval-censored survival outcomes.Genetic epidemiology · 2021Article
- Replication of GWAS significant loci in a sub-Saharan African Cohort with early childhood caries: a pilot study.BMC oral health · 2021Article
- Cohort Profile: ZOE 2.0-A Community-Based Genetic Epidemiologic Study of Early Childhood Oral Health.International journal of environmental research and public health · 2020Article
- The building blocks of precision oral health in early childhood: the ZOE 2.0 study.Journal of public health dentistry · 2020Article
- Role of diet in ECC affected South Indian children assessed by the HEI-2005: A pilot study.Journal of family medicine and primary care · 2020Article
- Genomics of periodontal disease and tooth morbidity.Periodontology 2000 · 2020Review
- Searching Deep and Wide: Advances in the Molecular Understanding of Dental Caries and Periodontal Disease.Advances in dental research · 2019Article
- Pilot GWAS of caries in African-Americans shows genetic heterogeneity.BMC oral health · 2019Article
- The Era of the Genome and Dental Medicine.Journal of dental research · 2019Review
- Human genes influence the interaction between Streptococcus mutans and host caries susceptibility: a genome-wide association study in children with primary dentition.International journal of oral science · 2019Article
- The Supragingival Biofilm in Early Childhood Caries: Clinical and Laboratory Protocols and Bioinformatics Pipelines Supporting Metagenomics, Metatranscriptomics, and Metabolomics Studies of the Oral Microbiome.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Protocols, Methods, and Tools for Genome-Wide Association Studies (GWAS) of Dental Traits.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Measurement of Early Childhood Oral Health for Research Purposes: Dental Caries Experience and Developmental Defects of the Enamel in the Primary Dentition.Methods in molecular biology (Clifton, N.J.) · 2019Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveA genetic component in early childhood caries (ECC) is theorized, but no genome-wide investigations of ECC have been conducted. This pilot study is part of a long-term research program aimed to: (1) determine the proportion of ECC variance attributable to the human genome and (2) identify ECC-associated genetic loci.
methodsThe study's community-based sample comprised 212 children (mean age=39 months; range = 30-52 months; males = 55%; Hispanic/Latino = 35%, African-American = 32%; American Academy of Pediatric Dentistry definition of ECC prevalence = 38%). Approximately 2.4 million single nucleotide polymorphisms (SNPs) were genotyped using DNA purified from saliva. A P < 5 × 10
resultsSNPs with minor allele frequency ≥5% explained 52% (standard error = 54%) of ECC variance (one-sided P = 0.03). Unsurprisingly, given the pilot's small sample size, no genome-wide significant associations were found. An intergenic locus on 4q32 (rs4690994) displayed the strongest association with ECC [P = 2.3 × 10
conclusionThis study's findings support a heritable component of ECC and demonstrate the feasibility of conducting genomics studies among preschool-age children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.