Evidence map›Paper›PMID 29057454›Full record

ArticleBritish journal of pharmacology2018

Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5-HT

Roger G Pertwee, Erin M Rock, Kelsey Guenther, Cheryl L Limebeer, Lesley A Stevenson, Christeene Haj, Reem Smoum, Linda A Parker, Raphael Mechoulam

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 64 citations in OpenAlex.

  1. Review
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  6. The Use of Compounds Derived fromInternational journal of molecular sciences · 2024
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  14. Effects of Cannabidiol on Locomotor Activity.Life (Basel, Switzerland) · 2022
    Review
  15. Review
  16. Evaluation of the Possible Anticonvulsant Effect of ΔCannabis and cannabinoid research · 2022
    Article
  17. Review
  18. Article
  19. Article
  20. Cannabinoids and Cancer Chemotherapy-Associated Adverse Effects.Journal of the National Cancer Institute. Monographs · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Roger G PertweeSchool of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.ORCID 0000-0003-3227-2783
Erin M RockDepartment of Psychology and Neuroscience Graduate Program, University of Guelph, Guelph, ON, Canada.
Kelsey GuentherDepartment of Psychology and Neuroscience Graduate Program, University of Guelph, Guelph, ON, Canada.
Cheryl L LimebeerDepartment of Psychology and Neuroscience Graduate Program, University of Guelph, Guelph, ON, Canada.
Lesley A StevensonSchool of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Christeene HajInstitute for Drug Research, Medical Faculty, Hebrew University, Jerusalem, Israel.
Reem SmoumInstitute for Drug Research, Medical Faculty, Hebrew University, Jerusalem, Israel.
Linda A ParkerDepartment of Psychology and Neuroscience Graduate Program, University of Guelph, Guelph, ON, Canada.ORCID 0000-0002-3494-9754
Raphael MechoulamInstitute for Drug Research, Medical Faculty, Hebrew University, Jerusalem, Israel.
University of Guelph · CAHebrew University of Jerusalem · ILUniversity of Aberdeen · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe aim of this study was to compare the abilities of cannabidiolic acid methyl ester (HU-580) and cannabidiolic acid (CBDA) to enhance 5-HT EXPERIMENTAL APPROACH: We investigated the effects of HU-580 and CBDA on (i) activation by 8-hydroxy-2-(di-n-propylamino)tetralin of human 5-HT KEY

resultsHU-580 and CBDA increased the E CONCLUSIONS AND IMPLICATIONS: HU-580 is more potent than CBDA at enhancing 5-HT

Indexed as

AnimalsAnti-Anxiety AgentsAntiemeticsAnxietyCannabinoidsCHO CellsCricetinaeCricetulusDose-Response Relationship, DrugHumansMaleNauseaRatsRats, Sprague-DawleyReceptor, Serotonin, 5-HT1ASerotonin 5-HT1 Receptor AgonistsAnti-Anxiety AgentsAntiemeticscannabidiolic acidCannabinoidsHTR1A protein, humanReceptor, Serotonin, 5-HT1ASerotonin 5-HT1 Receptor Agonists

Identifiers

PMID29057454
PMCPMC5740240
OpenAlexW2765935614

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.