Evidence map›Paper›PMID 29057388›Full record

ArticleClinical and experimental psychology2017

Overlapping Risky Decision-Making and Olfactory Processing Ability in HIV-Infected Individuals.

Christopher Jackson, Narayan Rai, Charlee K McLean, Maria Mananita S Hipolito, Flora Terrell Hamilton, Suad Kapetanovic, Evaristus A Nwulia

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental psychology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04850664 (Development and Evaluation of Computerized Chemosensory-Based Orbitofrontal Cortex Training), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04850664 phase2unknown statusnot on this mapstarted 2021, after this paper: background citation

Development and Evaluation of Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) for Opioid Use Disorder

TypeinterventionalSponsorEvon Medics LLCRan2021 to 2022Enrolled190ConditionsOpioid Use Disorder, Moderate, Opioid Use Disorder, Severe, Withdrawal Symptoms, CravingArmsCBOT + TAU, Sham + TAU
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Christopher JacksonCollege of Medicine, Howard University, USA.
Narayan RaiDepartment of Psychiatry, Howard University, Georgia Ave., NW, Washington, DC, USA.
Charlee K McLeanDepartment of Psychiatry, Howard University, Georgia Ave., NW, Washington, DC, USA.
Maria Mananita S HipolitoDepartment of Psychiatry, Howard University, Georgia Ave., NW, Washington, DC, USA.
Flora Terrell HamiltonFamily and Medical Counseling Service, Inc., Washington, DC, USA.
Suad KapetanovicDepartment of Psychiatry, Keck School of Medicine, Los Angeles, CA, USA.
Evaristus A NwuliaDepartment of Psychiatry, Howard University, Georgia Ave., NW, Washington, DC, USA.
Howard University · USFamily and Medical Counseling Service · US

Funding

Mediators of Lithium Action in Olfactory EpitheliumR01MH091460 · NIMH · HOWARD UNIVERSITY · PI NWULIA, EVARISTUS A · 2011 to 2015
$2.8M
Development and Evaluation of Computerized Olfactory Training Program (COT) for Cognitive Decline in Early Alzheimer's Disease (AD)R44AG061981 · NIA · EVON MEDICS, LLC · PI NWAOKOBIA, CHARLES CHIEDU, NWULIA, EVARISTUS A · 2021 to 2022
$2.6M
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENIA NIH HHS R44 AG061981NIMH NIH HHS R01 MH091460
6 · The paper itself

Abstract

objectiveGiven neuroimaging evidences of overlap in the circuitries for decision-making and olfactory processing, we examined the hypothesis that impairment in psychophysical tasks of olfaction would independently predict poor performances on Iowa Gambling Task (IGT), a laboratory task that closely mimics real-life decision-making, in a US cohort of HIV-infected (HIV+) individuals.

methodIGT and psychophysical tasks of olfaction were administered to a Washington DC-based cohort of largely African American HIV+ subjects (N=100), and to a small number of demographically-matched non-HIV healthy controls (N=43) from a different study. Constructs of olfactory ability and decision-making were examined through confirmatory factor analysis (CFA). Structural equation models (SEMs) were used to evaluate the validity of the path relationship between these two constructs.

resultThe 100 HIV+ participants (56% female; 96% African Americans; median age = 48 years) had median CD4 count of 576 cells/μl and median HIV RNA viral load <48 copies per milliliter. Majority of HIV+ participants performed randomly throughout the course of IGT tasks, and failed to demonstrate a learning curve. Confirmatory factor analysis provided support for a unidimensional factor underlying poor performances on IGT. Nomological validity for correlations between olfactory ability and IGT performance was confirmed through SEM. Finally, factor scores of olfactory ability and IGT performance strongly predicted 6 months history of drug use, while olfaction additionally predicted hallucinogen use.

conclusionThis study suggests that combination of simple, office-based tasks of olfaction and decision-making may identify those HIV+ individuals who are more prone to risky decision-making. This finding may have significant clinical, public health value if joint impairments in olfaction and IGT task correlates with more decreased activity in brain regions relevant to decision-making.

Indexed as

Cognitive functionHIVIowa Gambling TaskOlfaction

Identifiers

PMID29057388
PMCPMC5648356
OpenAlexW2761102123

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.