Evidence map›Paper›PMID 29057374›Full record

ArticleJACC. Basic to translational science2017

A Sarcoplasmic Reticulum Localized Protein Phosphatase Regulates Phospholamban Phosphorylation and Promotes Ischemia Reperfusion Injury in the Heart.

Toru Akaike, Na Du, Gang Lu, Susumu Minamisawa, Yibin Wang, Hongmei Ruan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Stress-Induced calcium mishandling in cardiac (Patho)physiology.Cellular and molecular life sciences : CMLS · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. p38 MAPK Pathway in the Heart: New Insights in Health and Disease.International journal of molecular sciences · 2020
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Quantitative proteomic and phosphoproteomic profiling of ischemic myocardial stunning in swine.American journal of physiology. Heart and circulatory physiology · 2020
    Article
  16. Article
  17. Article
  18. Review
  19. Negative Adrenergic Feedback Specific to Phospholamban.JACC. Basic to translational science · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Toru AkaikeDepartment of Anesthesiology and Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095-1735.
Na DuDepartment of Anesthesiology and Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095-1735.
Gang LuDepartment of Anesthesiology and Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095-1735.
Susumu MinamisawaDepartment of Cell Physiology, The Jikei University School of Medicine.
Yibin WangDepartment of Anesthesiology and Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095-1735.
Hongmei RuanDepartment of Anesthesiology and Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095-1735.
University of California, Los Angeles · USJikei University School of Medicine · JP

Funding

Novel mechanisms in ER regulation in heartR01HL070079 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANG, YIBIN · 2003 to 2011
$3.2M
Novel Signaling Mechanisms and Molecular Targets in the Stressed MyocardiumR01HL098954 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PING, PEIPEI, WANG, YIBIN · 2010 to 2013
$3.0M
Novel Mechanism of SR Calcium Regulation in Cardiac DysfunctionR01HL108186 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANG, YIBIN · 2011 to 2015
$1.9M
NHLBI NIH HHS R01 HL070079NHLBI NIH HHS R01 HL098954NHLBI NIH HHS R01 HL108186
6 · The paper itself

Abstract

Phospholamban (PLN) is a key regulator of sarcolemma calcium uptake in cardiomyocyte, its inhibitory activity to SERCA is regulated by phosphorylation. PLN hypophosphorylation is a common molecular feature in failing heart. The current study provided evidence at molecular, cellular and whole heart levels to implicate a sarcolemma membrane targeted protein phosphatase, PP2Ce, as a specific and potent PLN phosphatase. PP2Ce expression was elevated in failing human heart and induced acutely at protein level by β -adrenergic stimulation or oxidative stress in cardiomyocytes. PP2Ce expression in mouse heart blunted β-adrenergic response and exacerbated ischemia/reperfusion injury. Therefore, PP2Ce is a new regulator for cardiac function and pathogenesis.

Indexed as

heartPhosphalambanPhosphatase

Identifiers

PMID29057374
PMCPMC5648354
OpenAlexW2608891406

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.