Evidence map›Paper›PMID 29057334›Full record

ArticleHeliyon2017

Antouka Super

Ngoula Ferdinand, Ngoumtsop Victor Herman, Ngouateu Kenfack Omer Bebe, Kenfack Augustave, Mutwedu Valence, Nguemmogne Tamdem Ghislaine, Tchoffo Herve, Azafack Kana Dorice, Deutcheu Sorelle, Manjeli Yacouba

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ngoula FerdinandLaboratory of Animal Physiology and Health, Department of Animal Science, Faculty of Agronomy and Agricultural Sciences, University of Dschang, P.O. Box 188, Dschang, Cameroon.
Ngoumtsop Victor HermanLaboratory of Animal Physiology and Health, Department of Animal Science, Faculty of Agronomy and Agricultural Sciences, University of Dschang, P.O. Box 188, Dschang, Cameroon.
Ngouateu Kenfack Omer BebeLaboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
Kenfack AugustaveLaboratory of Animal Physiology and Health, Department of Animal Science, Faculty of Agronomy and Agricultural Sciences, University of Dschang, P.O. Box 188, Dschang, Cameroon.
Mutwedu ValenceLaboratory of Animal Physiology and Health, Department of Animal Science, Faculty of Agronomy and Agricultural Sciences, University of Dschang, P.O. Box 188, Dschang, Cameroon.
Nguemmogne Tamdem GhislaineLaboratory of Animal Physiology and Health, Department of Animal Science, Faculty of Agronomy and Agricultural Sciences, University of Dschang, P.O. Box 188, Dschang, Cameroon.
Tchoffo HerveLaboratory of Animal Physiology and Health, Department of Animal Science, Faculty of Agronomy and Agricultural Sciences, University of Dschang, P.O. Box 188, Dschang, Cameroon.
Azafack Kana DoriceLaboratory of Animal Physiology and Health, Department of Animal Science, Faculty of Agronomy and Agricultural Sciences, University of Dschang, P.O. Box 188, Dschang, Cameroon.
Deutcheu SorelleLaboratory of Animal Physiology and Health, Department of Animal Science, Faculty of Agronomy and Agricultural Sciences, University of Dschang, P.O. Box 188, Dschang, Cameroon.
Manjeli YacoubaLaboratory of Animal Physiology and Health, Department of Animal Science, Faculty of Agronomy and Agricultural Sciences, University of Dschang, P.O. Box 188, Dschang, Cameroon.
Université de Dschang · CMUniversité de Yaoundé I · CM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntouka Super

objectiveThe present study was undertaken to evaluate the effect of AS on the serum testosterone, oxidative stress biomarkers, testis histology and fertility of male Japanese quail.

methodsThirty-two (32) male Japanese quails twenty-eight (28) days were randomly divided into four groups: C0 (control), T1, T2 and T3, exposed daily (gavage) to 0, 37.5, 56.25 and 75 mg of AS/kg body weight (b.w), respectively, for 49 consecutive days and were analysed for fertility. Control and experimental male quails were cohabited, for two days, with untreated female quails and sperm positive female quail were analysed for paternal-mediated toxicity. After completion of fertility studies quails were sacrificed and analysed for reproductive endpoints.

resultsThere was a dose dependent decrease of the relative weight of testis, epididymis and vas deferens. Additionally, testis total proteins and serum testosterone levels were decreased in AS treated quails (p < 0.05). A decrease of sperm motility, viability and concentration per vas deferens, and an increase of sperm anomalies were recorded in AS exposed quails with respect to the controls. The embryonic and post-embryonic mortality rate were significantly (p < 0.05) higher in group T3 (25.00 ± 3.40% and 31.66 ± 10.22% respectively) than in control group (6.25 ± 3.98% and 9.54 ± 3.72% respectively). The superoxide dismutase (SOD), total peroxidase (POD) and catalase activity (CAT) were significantly (p < 0.05) lower treated than control quails, while the level of malondialdehyde (MDA) was significantly (p < 0.05) higher in groups T1, T2 and T3 (13.00 ± 0.96, 23.50 ± 1.35 and 29.08 ± 1.58 nmol/mg tissues respectively) compared to the control one (9.32 ± 0.67nmol/mg tissues). Histopathological examination of the testes of AS treated quails revealed testicular lesions characterized by moderate to severe degenerative changes of seminiferous tubules, incomplete spermatogenesis and depletion in the germ layers of seminiferous tubules in which immature spermatozoa were hardly seen.

conclusionFrom the above study, it can be inferred that AS (56.25 and 75) mg/kg b.w decrease body and relative organ weights and induces testicular lesions. Also, AS increases the level of MDA while it reduces the levels of enzymatic antioxidant biomarkers, serum testosterone and reproductive indices of intoxicated quails and their offspring. However, further work is needed to establish the genetic toxicology and immunohistochemistry of caspase-3 and claudin-1.

Indexed as

Biological sciencesPhysiologyToxicology

Identifiers

PMID29057334
PMCPMC5639044
OpenAlexW2761034143

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.