ArticleScience advances2017
Accelerating metabolism and transmembrane cation flux by distorting red blood cells.
Article in Science advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Deoxy-Piezo1 hyperactivity elevates pump-leak fluxes and lactate production in sickle cells.Biophysical journal · 2026Article
- Mechanotransduction mechanisms in human erythrocytes: Fundamental physiology and clinical significance.Channels (Austin, Tex.) · 2025Review
- Buckling of red blood cell membrane in narrow capillaries induces excessive wall shear stress.Biophysical journal · 2025Article
- Hyperactive deoxy-PIEZO1 shapes the circulatory life cycle of irreversibly sickled cells.Biophysical journal · 2025Article
- Disrupting NaCancer & metabolism · 2024Article
- Roles of mechanosensitive ion channels in immune cells.Heliyon · 2024Review
- Activation of Piezo1 channels in compressed red blood cells augments platelet-driven contraction of blood clots.Journal of thrombosis and haemostasis : JTH · 2023Article
- Multiple quantum filtered nuclear magnetic resonance of 23Na+ in uniformly stretched and compressed hydrogels.The Journal of chemical physics · 2023Article
- Gsmtx4 Alleviated Osteoarthritis through Piezo1/Calcineurin/NFAT1 Signaling Axis under Excessive Mechanical Strain.International journal of molecular sciences · 2023Article
- The circulatory dynamics of human red blood cell homeostasis: Oxy-deoxy and PIEZO1-triggered changes.Biophysical journal · 2023Article
- Fatigue of red blood cells under periodic squeezes in ECMO.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Piezo channels in the urinary system.Experimental & molecular medicine · 2022Review
- Fluorescence-coupled micropipette aspiration assay to examine calcium mobilization caused by red blood cell mechanosensing.European biophysics journal : EBJ · 2022Article
- A Deadly Embrace: Hemagglutination Mediated by SARS-CoV-2 Spike Protein at Its 22 N-Glycosylation Sites, Red Blood Cell Surface Sialoglycoproteins, and Antibody.International journal of molecular sciences · 2022Review
- Surface model of the human red blood cell simulating changes in membrane curvature under strain.Scientific reports · 2021Article
- An Insight into the Stages of Ion Leakage during Red Blood Cell Storage.International journal of molecular sciences · 2021Article
- Correlated flickering of erythrocytes membrane observed with dual time resolved membrane fluctuation spectroscopy under different D-glucose concentrations.Scientific reports · 2021Article
- Trends in Piezo Channel Research Over the Past Decade: A Bibliometric Analysis.Frontiers in pharmacology · 2021Article
- Effect of red blood cell shape changes on haemoglobin interactions and dynamics: a neutron scattering study.Royal Society open science · 2020Article
- Erythroid glucose transport in health and disease.Pflugers Archiv : European journal of physiology · 2020Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Under static conditions, mammalian red blood cells (RBCs) require a continuous supply of energy, typically via glucose, to maintain their biconcave disc shape. Mechanical distortion, in a complementary way, should lead to increased energy demand that is manifest in accelerated glycolysis. The experimental challenge in observing this phenomenon was met by reversibly and reproducibly distorting the cells and noninvasively measuring glycolytic flux. This was done with a gel-distorting device that was coupled with
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.