Evidence map›Paper›PMID 29057298›Full record

ArticleChemPhotoChem2017

Saposin B Binds the Lipofuscin Bisretinoid A2E and Prevents its Enzymatic and Photooxidation.

Jay Tinklepaugh, Britannia M Smith, Yan Nie, Kelsey Moody, Kris Grohn, Fadi Bou-Abdallah, Robert P Doyle

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemPhotoChem, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jay TinklepaughDepartment of Chemistry, Syracuse University, Syracuse, NY 13244 (USA).
Britannia M SmithDepartment of Chemistry, State University of New York at Potsdam, Potsdam, NY 13676 (USA).
Yan NieDepartment of Chemistry, Syracuse University, Syracuse, NY 13244 (USA).
Kelsey MoodyICHOR Therapeutics, 2521 US-11, Lafayette, NY 13084 (USA).
Kris GrohnICHOR Therapeutics, 2521 US-11, Lafayette, NY 13084 (USA).
Fadi Bou-AbdallahDepartment of Chemistry, State University of New York at Potsdam, Potsdam, NY 13676 (USA).
Robert P DoyleDepartment of Chemistry, Syracuse University, Syracuse, NY 13244 (USA).
Io Therapeutics (United States) · USState University of New York at Potsdam · USSyracuse University · USSUNY Upstate Medical University · US

Funding

Heteropolymer Ferritins Structure-Function StudiesR15GM104879 · NIGMS · STATE UNIVERSITY OF NEW YORK AT POTSDAM · PI BOU-ABDALLAH, FADI · 2015 to 2019
$675k
NIGMS NIH HHS R15 GM104879
6 · The paper itself

Abstract

Vitamin A based bisretinoid accumulation is a major focus in the study of macular degeneration. Whether specific endogenous lysosomal proteins can bind A2E, a pronounced bisretinoid in lipofuscin granules in retinal pigment epithelial cells, and interfere with enzymatic or photoinduced oxidation of such, has not been explored. Herein, using fluorescence and electronic absorption spectroscopy and mass spectrometry, we demonstrate that Saposin B, a critical protein in the degradation of sulfatides and "flushing" of lipids, can bind A2E, preventing its H

Indexed as

bisretinoidsenzymatic oxidationmacular degenerationphotooxidationsaposin B

Identifiers

PMID29057298
PMCPMC5646234
OpenAlexW4210712891

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.