Evidence map›Paper›PMID 29057276›Full record

ArticleSpirituality in clinical practice (Washington, D.C.)2017

Genetic Correlates of Spirituality/Religion and Depression: A Study in Offspring and Grandchildren at High and Low Familial Risk for Depression.

Micheline R Anderson, Lisa Miller, Priya Wickramaratne, Connie Svob, Zagaa Odgerel, Ruixin Zhao, Myrna M Weissman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Spirituality in clinical practice (Washington, D.C.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 64 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Micheline R AndersonTeachers College, Columbia University, New York, NY.
Lisa MillerTeachers College, Columbia University, New York, NY.
Priya WickramaratneDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Connie SvobDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Zagaa OdgerelDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Ruixin ZhaoDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Myrna M WeissmanDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
New York Psychoanalytic Society and Institute · USColumbia University · US

Funding

Three Generations at High and Low Risk for Depression Followed LongitudinallyR01MH036197 · NIMH · YALE UNIVERSITY · PI POSNER, JONATHAN E, WEISSMAN, MYRNA M · 1985 to 2020
$15.0M
Serotonergic Modulation of Brain Development: Genetic and Pharmacologic InfluencP50MH090966 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI POSNER, JONATHAN E · 2010 to 2014
$9.6M
NIMH NIH HHS P50 MH090966NIMH NIH HHS R01 MH036197
6 · The paper itself

Abstract

rationalePossible genetic correlates of spirituality and depression have been identified in community samples. We investigate some of the previously identified candidates in a sample of families at both high and low-risk for depression.

methodOffspring and grandchildren of individuals at high and low-risk for depression, participating in a multi-wave thirty-year longitudinal study, were assessed for seven SNPS drawn from four single gene candidates associated with systems implicated in both depression and spirituality: Serotonin (5-HT1B and 5-HT2A), Dopamine (DRD2), Oxytocin (OT) and Monoamine Vesicular Transporter (VMAT1).

resultsDopamine (DRD2) Serotonin (5-HT1B), their Transporter (VMAT1) and Oxytocin (OXTR) were positively associated with a high level of importance of spirituality or religion (S/R) in the group at low familial risk for depression. DRD2 minor allele was associated with both lifetime major depressive disorder (MDD) and spirituality in the low-risk group for depression. No SNPs were related to S/R in the group at high familial risk for depression. OXTR was associated with lifetime MDD in the full sample.

conclusionGenes for dopamine, serotonin, their vesicular transporter, and oxytocin may be associated with S/R in people at low familial risk for depression. Genes for dopamine may be associated both with S/R and increased risk for depression in people at low-risk for depression, suggesting a common pathway or physiology to mild to moderate depression. MDD is associated with oxytocin across risk groups. In the high-risk group, phenotypic expression of S/R may be suppressed. IMPLICATIONS: The shared association of DRD2 by S/R and depression, generally found to be inversely related, calls for further research on their common physiological pathways, and the phenotypic expression of these pathways based upon use and environment. Prevention for offspring at high familial risk for depression might include support for the development of child spirituality.

Identifiers

PMID29057276
PMCPMC5646707
OpenAlexW2606797716

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